p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

Background & Aims: TP53 is a potent tumour suppressor that coordinates diverse stress response programmes, ranging from pro-survival activities to cell death. p53 is also engaged during tissue damage and repair, including within the liver. Metabolic dysfunction-associated steatohepatitis (MA...

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Bibliographic Details
Main Authors: Celine I. Wittke, Eric C. Cheung, Dimitris Athineos, Nicola Clements, Liam Butler, Mark Hughes, Vivienne Morrison, Dale M. Watt, Karen Blyth, Karen H. Vousden, Timothy J. Humpton
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:JHEP Reports
Subjects:
p53
Metabolic dysregulation
TIGAR
ROS
MASH
NASH
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925000746
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