Impact of adding carboplatin to docetaxel chemotherapy on testosterone levels and treatment outcomes in metastatic docetaxel-resistant prostate cancer

Impact of adding carboplatin to docetaxel chemotherapy on testosterone levels and treatment outcomes in metastatic docetaxel-resistant prostate cancer

Abstract Docetaxel resistance, particularly post-androgen-receptor targeted therapy (ART), undermines its clinical utility in metastatic castration-resistant prostate cancer (mCRPC). This study explores the impact of docetaxel plus carboplatin (DC) chemotherapy on serum testosterone levels in metast...

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Bibliographic Details
Main Authors: Hejar Atalan, Michael A. Morgan, Philipp Ivanyi, Paula Kappler, Florian H. Heidel, Christoph W. M. Reuter
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Prostate cancer
Docetaxel resistance
Carboplatin
Testosterone
Online Access:https://doi.org/10.1038/s41598-025-04667-0
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