Antioxidant and Photoprotective Activity of Bromelain Cream: An In Vitro and In Vivo Study
Bromelain, a natural enzyme derived from pineapple, is known for its antioxidant properties, and its potential as a photoprotective agent has garnered interest in skincare applications. The primary objective of this research was to evaluate and optimize the effectiveness of bromelain-based creams in...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Series: | Cosmetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9284/12/2/41 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849715119713419264 |
|---|---|
| author | Zahra Marissa Soraya Ratnawulan Mita Cahya Khairani Kusumawulan Sriwidodo Sriwidodo |
| author_facet | Zahra Marissa Soraya Ratnawulan Mita Cahya Khairani Kusumawulan Sriwidodo Sriwidodo |
| author_sort | Zahra Marissa |
| collection | DOAJ |
| description | Bromelain, a natural enzyme derived from pineapple, is known for its antioxidant properties, and its potential as a photoprotective agent has garnered interest in skincare applications. The primary objective of this research was to evaluate and optimize the effectiveness of bromelain-based creams in providing antioxidant and photoprotective protection against ultraviolet (UV) radiation. Antioxidant activity was assessed using the DPPH radical scavenging assay, and the Sun Protection Factor (SPF) was determined in vitro and in vivo to evaluate photoprotective activity. The results revealed that bromelain exhibited strong antioxidant activity. Photoprotection, as measured by SPF, the formulation F3, which combined bromelain with other UV filters, exhibited the highest SPF values of 22.043 ± 0.277 (in vitro) and 21.3 ± 2.901 (in vivo), indicating enhanced photoprotective efficacy. This improvement in SPF was likely due to the synergistic effect of bromelain with the UV filters Octyl Methoxycinnamate (OMC). The findings suggest a positive correlation between antioxidant activity and photoprotection, with bromelain’s antioxidant properties contributing to its overall photoprotective effect. Bromelain may be used on people without causing skin or eye irritation. This study supports the potential of bromelain-based creams as dual-action skincare formulations, offering both antioxidant and UV protection. |
| format | Article |
| id | doaj-art-2b04301f0ad341fbbdec90b791e044a8 |
| institution | DOAJ |
| issn | 2079-9284 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj-art-2b04301f0ad341fbbdec90b791e044a82025-08-20T03:13:30ZengMDPI AGCosmetics2079-92842025-02-011224110.3390/cosmetics12020041Antioxidant and Photoprotective Activity of Bromelain Cream: An In Vitro and In Vivo StudyZahra Marissa0Soraya Ratnawulan Mita1Cahya Khairani Kusumawulan2Sriwidodo Sriwidodo3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Sumedang 45363, Jawa Barat, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Sumedang 45363, Jawa Barat, IndonesiaCV. Dian Indah Abadi, Cosmetics Industry, Bandung 40394, West Java, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Sumedang 45363, Jawa Barat, IndonesiaBromelain, a natural enzyme derived from pineapple, is known for its antioxidant properties, and its potential as a photoprotective agent has garnered interest in skincare applications. The primary objective of this research was to evaluate and optimize the effectiveness of bromelain-based creams in providing antioxidant and photoprotective protection against ultraviolet (UV) radiation. Antioxidant activity was assessed using the DPPH radical scavenging assay, and the Sun Protection Factor (SPF) was determined in vitro and in vivo to evaluate photoprotective activity. The results revealed that bromelain exhibited strong antioxidant activity. Photoprotection, as measured by SPF, the formulation F3, which combined bromelain with other UV filters, exhibited the highest SPF values of 22.043 ± 0.277 (in vitro) and 21.3 ± 2.901 (in vivo), indicating enhanced photoprotective efficacy. This improvement in SPF was likely due to the synergistic effect of bromelain with the UV filters Octyl Methoxycinnamate (OMC). The findings suggest a positive correlation between antioxidant activity and photoprotection, with bromelain’s antioxidant properties contributing to its overall photoprotective effect. Bromelain may be used on people without causing skin or eye irritation. This study supports the potential of bromelain-based creams as dual-action skincare formulations, offering both antioxidant and UV protection.https://www.mdpi.com/2079-9284/12/2/41bromelainantioxidantphotoprotectionin-vitroin-vivo |
| spellingShingle | Zahra Marissa Soraya Ratnawulan Mita Cahya Khairani Kusumawulan Sriwidodo Sriwidodo Antioxidant and Photoprotective Activity of Bromelain Cream: An In Vitro and In Vivo Study Cosmetics bromelain antioxidant photoprotection in-vitro in-vivo |
| title | Antioxidant and Photoprotective Activity of Bromelain Cream: An In Vitro and In Vivo Study |
| title_full | Antioxidant and Photoprotective Activity of Bromelain Cream: An In Vitro and In Vivo Study |
| title_fullStr | Antioxidant and Photoprotective Activity of Bromelain Cream: An In Vitro and In Vivo Study |
| title_full_unstemmed | Antioxidant and Photoprotective Activity of Bromelain Cream: An In Vitro and In Vivo Study |
| title_short | Antioxidant and Photoprotective Activity of Bromelain Cream: An In Vitro and In Vivo Study |
| title_sort | antioxidant and photoprotective activity of bromelain cream an in vitro and in vivo study |
| topic | bromelain antioxidant photoprotection in-vitro in-vivo |
| url | https://www.mdpi.com/2079-9284/12/2/41 |
| work_keys_str_mv | AT zahramarissa antioxidantandphotoprotectiveactivityofbromelaincreamaninvitroandinvivostudy AT sorayaratnawulanmita antioxidantandphotoprotectiveactivityofbromelaincreamaninvitroandinvivostudy AT cahyakhairanikusumawulan antioxidantandphotoprotectiveactivityofbromelaincreamaninvitroandinvivostudy AT sriwidodosriwidodo antioxidantandphotoprotectiveactivityofbromelaincreamaninvitroandinvivostudy |