Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering
Flavonoids are a diverse class of plant polyphenols with essential roles in development, defense, and environmental adaptation, as well as significant applications in medicine, nutrition, and cosmetics. However, their naturally low abundance in plant tissues poses a major barrier to large-scale util...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2025.1597007/full |
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| author | Yuan Wang Jiahong Chen Genhe He Li Yin Yonghui Liao |
| author_facet | Yuan Wang Jiahong Chen Genhe He Li Yin Yonghui Liao |
| author_sort | Yuan Wang |
| collection | DOAJ |
| description | Flavonoids are a diverse class of plant polyphenols with essential roles in development, defense, and environmental adaptation, as well as significant applications in medicine, nutrition, and cosmetics. However, their naturally low abundance in plant tissues poses a major barrier to large-scale utilization. This review provides a comprehensive and forward-looking synthesis of flavonoid biosynthesis, regulation, transport, and yield enhancement strategies. We highlight key advances in understanding transcriptional and epigenetic control of flavonoid pathways, focusing on the roles of MYB, bHLH, and WD40 transcription factors and chromatin modifications. We also examine flavonoid transport mechanisms at cellular and tissue levels, supported by emerging spatial metabolomics data. Distinct from conventional reviews, this review explores how plant cell factories, genome editing, environmental optimization, and artificial intelligence (AI)-driven metabolic engineering can be integrated to boost flavonoid production. By bridging foundational plant science with synthetic biology and digital tools, this review outlines a novel roadmap for sustainable, high-yield flavonoid production with broad relevance to both research and industry. |
| format | Article |
| id | doaj-art-2b01a9ddbd3e4d139139de6839202ba2 |
| institution | DOAJ |
| issn | 1664-462X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj-art-2b01a9ddbd3e4d139139de6839202ba22025-08-20T03:12:47ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2025-05-011610.3389/fpls.2025.15970071597007Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineeringYuan Wang0Jiahong Chen1Genhe He2Li Yin3Yonghui Liao4Key Laboratory of Jiangxi Province for Functional Biology and Pollution Control in Red Soil Regions, School of Life Sciences, Jinggangshan University, Ji’an, ChinaKey Laboratory of Grain Crop Genetic Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs, Shanghai Agrobiological Gene Center, Shanghai, ChinaKey Laboratory of Jiangxi Province for Functional Biology and Pollution Control in Red Soil Regions, School of Life Sciences, Jinggangshan University, Ji’an, ChinaKey Laboratory of Jiangxi Province for Functional Biology and Pollution Control in Red Soil Regions, School of Life Sciences, Jinggangshan University, Ji’an, ChinaKey Laboratory of Jiangxi Province for Functional Biology and Pollution Control in Red Soil Regions, School of Life Sciences, Jinggangshan University, Ji’an, ChinaFlavonoids are a diverse class of plant polyphenols with essential roles in development, defense, and environmental adaptation, as well as significant applications in medicine, nutrition, and cosmetics. However, their naturally low abundance in plant tissues poses a major barrier to large-scale utilization. This review provides a comprehensive and forward-looking synthesis of flavonoid biosynthesis, regulation, transport, and yield enhancement strategies. We highlight key advances in understanding transcriptional and epigenetic control of flavonoid pathways, focusing on the roles of MYB, bHLH, and WD40 transcription factors and chromatin modifications. We also examine flavonoid transport mechanisms at cellular and tissue levels, supported by emerging spatial metabolomics data. Distinct from conventional reviews, this review explores how plant cell factories, genome editing, environmental optimization, and artificial intelligence (AI)-driven metabolic engineering can be integrated to boost flavonoid production. By bridging foundational plant science with synthetic biology and digital tools, this review outlines a novel roadmap for sustainable, high-yield flavonoid production with broad relevance to both research and industry.https://www.frontiersin.org/articles/10.3389/fpls.2025.1597007/fullflavonoid biosynthesistranscriptional regulationplant cell factorymetabolic engineeringartificial intelligence |
| spellingShingle | Yuan Wang Jiahong Chen Genhe He Li Yin Yonghui Liao Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering Frontiers in Plant Science flavonoid biosynthesis transcriptional regulation plant cell factory metabolic engineering artificial intelligence |
| title | Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering |
| title_full | Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering |
| title_fullStr | Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering |
| title_full_unstemmed | Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering |
| title_short | Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering |
| title_sort | unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering |
| topic | flavonoid biosynthesis transcriptional regulation plant cell factory metabolic engineering artificial intelligence |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2025.1597007/full |
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