The proline-rich antimicrobial peptide B7-005: low bacterial resistance, safe for human cells and effective in zebrafish embryo bacteraemia model

The proline-rich antimicrobial peptide B7-005: low bacterial resistance, safe for human cells and effective in zebrafish embryo bacteraemia model

Proline-rich antimicrobial peptides (PrAMPs) have gained attention due to their antimicrobial properties and low cytotoxicity. B7-005, a small optimized PrAMP, exhibits a broader spectrum of activity than native PrAMPs, due to an antimicrobial mechanism based on inhibiting prokaryotic protein synthe...

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Main Authors: Adriana Di Stasi, Sara Bozzer, Sabrina Pacor, Luigi de Pascale, Martino Morici, Lara Favero, Mariagiulia Spazzapan, Silvia Pegoraro, Roberta Bulla, Daniel N. Wilson, Paolo Macor, Marco Scocchi, Mario Mardirossian
Format: Article
Language:English
Published: The Royal Society 2024-12-01
Series:Open Biology
Subjects:
antimicrobial peptide
proline-rich
antibiotic resistance
protein synthesis
drug discovery
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240286
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