Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography
Background and aims: Despite technical advances, endoscopic retrograde cholangiopancreatography (ERCP) is associated with complications and potentially lethal outcomes. Sarcopenia, a complex syndrome mainly associated with aging, has been recognized as a predictor of poor surgical outcomes. Thus far...
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2024-12-01
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| author | Giacomo Mulinacci Clara Benedetta Conti Alberto Savino Davide Gandola Davide Ippolito Roberto Frego Alessandro Ettore Redaelli Marta Maino Marco Emilio Dinelli |
| author_facet | Giacomo Mulinacci Clara Benedetta Conti Alberto Savino Davide Gandola Davide Ippolito Roberto Frego Alessandro Ettore Redaelli Marta Maino Marco Emilio Dinelli |
| author_sort | Giacomo Mulinacci |
| collection | DOAJ |
| description | Background and aims: Despite technical advances, endoscopic retrograde cholangiopancreatography (ERCP) is associated with complications and potentially lethal outcomes. Sarcopenia, a complex syndrome mainly associated with aging, has been recognized as a predictor of poor surgical outcomes. Thus far, the impact of sarcopenia on ERCP remains unknown. The present study evaluates the role of sarcopenia as a predictor of ERCP-related outcomes in a cohort of elderly patients. Methods: Patients who underwent ERCP between June 2019 and January 2023 were retrospectively included. Demographic and procedure-associated data were collected. Sarcopenia was assessed using the skeletal muscle index (SMI) measured from a single axial slice through the L3 vertebra on a CT scan. ERCP-related outcomes were recorded. Univariate and multivariate analyses were used to assess the correlation between sarcopenia and procedural outcomes. Results: In total, 256 patients were enrolled, of whom 30 (11.7%) were sarcopenic. Cardiopulmonary complications of ERCP occurred in 3.5%. Sarcopenia was associated with higher 30-day and 12-month post-ERCP mortality (OR 3.45, <i>p</i> = 0.03; OR 3.87, <i>p</i> = 0.004) and longer hospitalization time (7 vs. 11 days, <i>p</i> = 0.003). Conclusions: SMI is an easy and objective index of sarcopenia that could be used to predict ERCP outcomes. Indeed, sarcopenia was independently associated with prolonged hospitalization and increased mortality in a retrospective cohort of elderly patients. |
| format | Article |
| id | doaj-art-2b0021509232403ab3436954229c04bd |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj-art-2b0021509232403ab3436954229c04bd2025-01-24T13:38:29ZengMDPI AGLife2075-17292024-12-011512110.3390/life15010021Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde CholangiopancreatographyGiacomo Mulinacci0Clara Benedetta Conti1Alberto Savino2Davide Gandola3Davide Ippolito4Roberto Frego5Alessandro Ettore Redaelli6Marta Maino7Marco Emilio Dinelli8Interventional Endoscopy Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, ItalyInterventional Endoscopy Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, ItalyDepartment of Medicine and Surgery, University of Milano Bicocca, 20126 Milan, ItalyDivision of Radiology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, ItalyDivision of Radiology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, ItalyInterventional Endoscopy Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, ItalyInterventional Endoscopy Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, ItalyInterventional Endoscopy Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, ItalyInterventional Endoscopy Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, ItalyBackground and aims: Despite technical advances, endoscopic retrograde cholangiopancreatography (ERCP) is associated with complications and potentially lethal outcomes. Sarcopenia, a complex syndrome mainly associated with aging, has been recognized as a predictor of poor surgical outcomes. Thus far, the impact of sarcopenia on ERCP remains unknown. The present study evaluates the role of sarcopenia as a predictor of ERCP-related outcomes in a cohort of elderly patients. Methods: Patients who underwent ERCP between June 2019 and January 2023 were retrospectively included. Demographic and procedure-associated data were collected. Sarcopenia was assessed using the skeletal muscle index (SMI) measured from a single axial slice through the L3 vertebra on a CT scan. ERCP-related outcomes were recorded. Univariate and multivariate analyses were used to assess the correlation between sarcopenia and procedural outcomes. Results: In total, 256 patients were enrolled, of whom 30 (11.7%) were sarcopenic. Cardiopulmonary complications of ERCP occurred in 3.5%. Sarcopenia was associated with higher 30-day and 12-month post-ERCP mortality (OR 3.45, <i>p</i> = 0.03; OR 3.87, <i>p</i> = 0.004) and longer hospitalization time (7 vs. 11 days, <i>p</i> = 0.003). Conclusions: SMI is an easy and objective index of sarcopenia that could be used to predict ERCP outcomes. Indeed, sarcopenia was independently associated with prolonged hospitalization and increased mortality in a retrospective cohort of elderly patients.https://www.mdpi.com/2075-1729/15/1/21sarcopeniamortalityendoscopic retrograde cholangiopancreatographyskeletal muscle indexCT scanelderly |
| spellingShingle | Giacomo Mulinacci Clara Benedetta Conti Alberto Savino Davide Gandola Davide Ippolito Roberto Frego Alessandro Ettore Redaelli Marta Maino Marco Emilio Dinelli Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography Life sarcopenia mortality endoscopic retrograde cholangiopancreatography skeletal muscle index CT scan elderly |
| title | Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography |
| title_full | Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography |
| title_fullStr | Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography |
| title_full_unstemmed | Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography |
| title_short | Sarcopenia as a Predictor of Mortality in a Cohort of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography |
| title_sort | sarcopenia as a predictor of mortality in a cohort of elderly patients undergoing endoscopic retrograde cholangiopancreatography |
| topic | sarcopenia mortality endoscopic retrograde cholangiopancreatography skeletal muscle index CT scan elderly |
| url | https://www.mdpi.com/2075-1729/15/1/21 |
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