Local oxygen concentration reversal from hyperoxia to hypoxia monitored by optical-resolution photoacoustic microscopy in inflammation-resolution process
Current consensus suggests a simultaneous occurrence of hypoxia and inflammation. For the first time, we observed a hyperoxia state during the initiation stage of gouty arthritis (GA) via optical-resolution photoacoustic microscopy. GA as a paradigm of acute sterile inflammation, has been regarded a...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597925000539 |
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| Summary: | Current consensus suggests a simultaneous occurrence of hypoxia and inflammation. For the first time, we observed a hyperoxia state during the initiation stage of gouty arthritis (GA) via optical-resolution photoacoustic microscopy. GA as a paradigm of acute sterile inflammation, has been regarded as a single process. However, our experimental results demonstrated that the onset-resolution inflammation process composed of two sub-processes with different features. In the initial sub-process, inflammation and resolution events appear in hyperoxia state (1st-5th days). In the subsequent sub-process, post-resolution events appear in hypoxia state (6th-15th days), which is related with the second wave of immune response. Furthermore, we demonstrated that the inflammatory cytokines together with hyperoxia levels in initial sub-process can be downregulated by photobiomodulation, resulting in the hypoxia levels in subsequent sub-process were inhibited. Our results unveiled the detailed progress of GA and provided potential non-invasive monitoring and treatment strategies. |
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| ISSN: | 2213-5979 |