Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial
BackgroundThis randomized placebo-controlled clinical trial aimed to evaluate the effect of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system.MethodsEighty healthy individuals were randomly assigned to four groups: oral caffeine capsules (100 mg caffeine)...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Oral Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1470531/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850277101812318208 |
|---|---|
| author | Kiarash Zare Mahva Talaei Amir Hesam Pahlevani Fahimeh Rezazadeh Kiana Zare Masumeh Akbaryari Mohammad Mehdi Naghizadeh Mojtaba Heydari Mojtaba Heydari Mohsen Goharinia |
| author_facet | Kiarash Zare Mahva Talaei Amir Hesam Pahlevani Fahimeh Rezazadeh Kiana Zare Masumeh Akbaryari Mohammad Mehdi Naghizadeh Mojtaba Heydari Mojtaba Heydari Mohsen Goharinia |
| author_sort | Kiarash Zare |
| collection | DOAJ |
| description | BackgroundThis randomized placebo-controlled clinical trial aimed to evaluate the effect of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system.MethodsEighty healthy individuals were randomly assigned to four groups: oral caffeine capsules (100 mg caffeine) as the control, brushing with caffeinated toothpaste (100 mg caffeine) for 2, 3, and 4 min. Cognitive and motor responses were assessed using selective processing speed assessment (Stroop test), short-term memory test, selective attention capacity assessment, and hand-eye coordination test before and after intervention at 10, 30, and 60 min intervals.ResultsBrushing with caffeinated toothpaste was as effective as oral caffeine intake in improving selective attention capacity, selective processing speed, short-term memory, and hand-eye coordination. Despite the higher improvement in the longest duration brushing group in most of the outcomes, the difference did not reach the statistical significance among study groups.ConclusionBrushing with caffeinated toothpaste appears to be as effective as oral intake of caffeine in enhance cognitive and motor functions.
Clinical Trial Registrationhttps://irct.behdasht.gov.ir/trial/71213, identifier (IRCT20230318057752N2). |
| format | Article |
| id | doaj-art-2af744c73bc6478ca238e56d43d73511 |
| institution | OA Journals |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj-art-2af744c73bc6478ca238e56d43d735112025-08-20T01:50:00ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-05-01610.3389/froh.2025.14705311470531Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trialKiarash Zare0Mahva Talaei1Amir Hesam Pahlevani2Fahimeh Rezazadeh3Kiana Zare4Masumeh Akbaryari5Mohammad Mehdi Naghizadeh6Mojtaba Heydari7Mojtaba Heydari8Mohsen Goharinia9Neuroscience Research Group, Student Research Committee, Fasa University of Medical Sciences, Fasa, IranNeuroscience Research Group, Student Research Committee, Fasa University of Medical Sciences, Fasa, IranNeuroscience Research Group, Student Research Committee, Fasa University of Medical Sciences, Fasa, IranDepartment of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, IranPoostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, IranResearch Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pharmacology, School of Medicine, Fasa University of Medical Sciences, Fasa, IranBackgroundThis randomized placebo-controlled clinical trial aimed to evaluate the effect of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system.MethodsEighty healthy individuals were randomly assigned to four groups: oral caffeine capsules (100 mg caffeine) as the control, brushing with caffeinated toothpaste (100 mg caffeine) for 2, 3, and 4 min. Cognitive and motor responses were assessed using selective processing speed assessment (Stroop test), short-term memory test, selective attention capacity assessment, and hand-eye coordination test before and after intervention at 10, 30, and 60 min intervals.ResultsBrushing with caffeinated toothpaste was as effective as oral caffeine intake in improving selective attention capacity, selective processing speed, short-term memory, and hand-eye coordination. Despite the higher improvement in the longest duration brushing group in most of the outcomes, the difference did not reach the statistical significance among study groups.ConclusionBrushing with caffeinated toothpaste appears to be as effective as oral intake of caffeine in enhance cognitive and motor functions. Clinical Trial Registrationhttps://irct.behdasht.gov.ir/trial/71213, identifier (IRCT20230318057752N2).https://www.frontiersin.org/articles/10.3389/froh.2025.1470531/fullcaffeinebrushingtoothpastecognitivememoryreaction |
| spellingShingle | Kiarash Zare Mahva Talaei Amir Hesam Pahlevani Fahimeh Rezazadeh Kiana Zare Masumeh Akbaryari Mohammad Mehdi Naghizadeh Mojtaba Heydari Mojtaba Heydari Mohsen Goharinia Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial Frontiers in Oral Health caffeine brushing toothpaste cognitive memory reaction |
| title | Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial |
| title_full | Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial |
| title_fullStr | Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial |
| title_full_unstemmed | Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial |
| title_short | Effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system: a randomized placebo-controlled clinical trial |
| title_sort | effects of brushing with caffeinated toothpaste on neurocognitive function of the central nervous system a randomized placebo controlled clinical trial |
| topic | caffeine brushing toothpaste cognitive memory reaction |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1470531/full |
| work_keys_str_mv | AT kiarashzare effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial AT mahvatalaei effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial AT amirhesampahlevani effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial AT fahimehrezazadeh effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial AT kianazare effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial AT masumehakbaryari effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial AT mohammadmehdinaghizadeh effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial AT mojtabaheydari effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial AT mojtabaheydari effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial AT mohsengoharinia effectsofbrushingwithcaffeinatedtoothpasteonneurocognitivefunctionofthecentralnervoussystemarandomizedplacebocontrolledclinicaltrial |