Mechanical Signal Transduction: A Key Role of Fluid Shear Forces in the Development of Osteoarthritis
Haitao Li, Wei Wang, Jian Wang Department of Orthopedics, Affiliated Hospital of Guizhou Medical University, Guiyang, 55000, People’s Republic of ChinaCorrespondence: Jian Wang, Email docwj11@163.comAbstract: Globally, osteoarthritis is a common and highly disabling disease that places a heavy burde...
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Dove Medical Press
2024-12-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/mechanical-signal-transduction-a-key-role-of-fluid-shear-forces-in-the-peer-reviewed-fulltext-article-JIR |
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| author | Li H Wang W Wang J |
| author_facet | Li H Wang W Wang J |
| author_sort | Li H |
| collection | DOAJ |
| description | Haitao Li, Wei Wang, Jian Wang Department of Orthopedics, Affiliated Hospital of Guizhou Medical University, Guiyang, 55000, People’s Republic of ChinaCorrespondence: Jian Wang, Email docwj11@163.comAbstract: Globally, osteoarthritis is a common and highly disabling disease that places a heavy burden on society and medical systems. The role of biomechanical factors in the development of osteoarthritis has gradually received more attention. As a key biomechanical stimulus, fluid shear force is becoming the focus of research for its dual role in maintaining cartilage health and disease progression. This paper conducts an in-depth discussion on the mechanism of fluid shear force in osteoarthritis and its impact on the disease process, aiming to reveal how fluid shear stress affects the development of osteoarthritis by regulating the physiological function and signal transduction pathways of chondrocytes.Keywords: fluid shear, osteoarthritis, chondrocytes, signal transduction, biomechanics |
| format | Article |
| id | doaj-art-2af1e477b4d844d88be8a9d2b973d0d3 |
| institution | OA Journals |
| issn | 1178-7031 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-2af1e477b4d844d88be8a9d2b973d0d32025-08-20T02:38:52ZengDove Medical PressJournal of Inflammation Research1178-70312024-12-01Volume 17101991020797896Mechanical Signal Transduction: A Key Role of Fluid Shear Forces in the Development of OsteoarthritisLi HWang WWang JHaitao Li, Wei Wang, Jian Wang Department of Orthopedics, Affiliated Hospital of Guizhou Medical University, Guiyang, 55000, People’s Republic of ChinaCorrespondence: Jian Wang, Email docwj11@163.comAbstract: Globally, osteoarthritis is a common and highly disabling disease that places a heavy burden on society and medical systems. The role of biomechanical factors in the development of osteoarthritis has gradually received more attention. As a key biomechanical stimulus, fluid shear force is becoming the focus of research for its dual role in maintaining cartilage health and disease progression. This paper conducts an in-depth discussion on the mechanism of fluid shear force in osteoarthritis and its impact on the disease process, aiming to reveal how fluid shear stress affects the development of osteoarthritis by regulating the physiological function and signal transduction pathways of chondrocytes.Keywords: fluid shear, osteoarthritis, chondrocytes, signal transduction, biomechanicshttps://www.dovepress.com/mechanical-signal-transduction-a-key-role-of-fluid-shear-forces-in-the-peer-reviewed-fulltext-article-JIRfluid shearosteoarthritischondrocytessignal transductionbomechanics. |
| spellingShingle | Li H Wang W Wang J Mechanical Signal Transduction: A Key Role of Fluid Shear Forces in the Development of Osteoarthritis Journal of Inflammation Research fluid shear osteoarthritis chondrocytes signal transduction bomechanics. |
| title | Mechanical Signal Transduction: A Key Role of Fluid Shear Forces in the Development of Osteoarthritis |
| title_full | Mechanical Signal Transduction: A Key Role of Fluid Shear Forces in the Development of Osteoarthritis |
| title_fullStr | Mechanical Signal Transduction: A Key Role of Fluid Shear Forces in the Development of Osteoarthritis |
| title_full_unstemmed | Mechanical Signal Transduction: A Key Role of Fluid Shear Forces in the Development of Osteoarthritis |
| title_short | Mechanical Signal Transduction: A Key Role of Fluid Shear Forces in the Development of Osteoarthritis |
| title_sort | mechanical signal transduction a key role of fluid shear forces in the development of osteoarthritis |
| topic | fluid shear osteoarthritis chondrocytes signal transduction bomechanics. |
| url | https://www.dovepress.com/mechanical-signal-transduction-a-key-role-of-fluid-shear-forces-in-the-peer-reviewed-fulltext-article-JIR |
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