Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis Gravidarum
Background: Hyperemesis gravidarum is a common cause of nausea and vomiting during the early gestational week. At the same time, it can also lead to an increase in liver enzyme values in patients due to or independently of underlying liver disease. This study aimed to evaluate fas...
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IMR Press
2024-09-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/51/9/10.31083/j.ceog5109206 |
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| author | Ayca Kubat Kucukyurt Arzu Cetin Cansel Tanrikulu Dilara Basat |
| author_facet | Ayca Kubat Kucukyurt Arzu Cetin Cansel Tanrikulu Dilara Basat |
| author_sort | Ayca Kubat Kucukyurt |
| collection | DOAJ |
| description | Background: Hyperemesis gravidarum is a common cause of nausea and vomiting during the early gestational week. At the same time, it can also lead to an increase in liver enzyme values in patients due to or independently of underlying liver disease. This study aimed to evaluate fasting bile acid (FBA) levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total and direct bilirubin, and urine ketone levels in pregnant women diagnosed with hyperemesis gravidarum (HG). Additionally, the study sought to investigate the relationship between HG and FBA levels. The diagnosis of HG remains primarily clinical, and identifying markers for disease severity is crucial. Methods: This retrospective cohort study obtained blood samples from 50 women diagnosed with HG and 25 healthy pregnant women. Serum levels of AST, ALT, total bilirubin (TBS), direct bilirubin, urine ketones, and FBA were measured. Statistical analysis was performed using the SPSS software version 28.0. Results: FBA levels were significantly higher in pregnant women diagnosed with HG compared to the healthy control group. Additionally, FBA levels increased simultaneously with ketonuria in the patient group. Our findings suggest that FBA levels can serve as a biomarker for diagnosing HG and indicating early-stage liver damage. Unlike previous studies, our research focused on the relationship between FBA levels and HG, providing valuable insights for future studies. Conclusions: FBA levels show promise as an objective biomarker for diagnosing HG and indicating early-stage liver damage. Further research with larger cohorts is necessary to validate these findings. |
| format | Article |
| id | doaj-art-2aeef3cdad274c90ad8db1ee1bbb73ca |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | IMR Press |
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| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-2aeef3cdad274c90ad8db1ee1bbb73ca2025-08-20T02:01:42ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-09-0151920610.31083/j.ceog5109206S0390-6663(24)02446-1Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis GravidarumAyca Kubat Kucukyurt0Arzu Cetin1Cansel Tanrikulu2Dilara Basat3Department of Obstetrics and Gynecology, Istanbul Training and Research Hospital, 34098 Istanbul, TurkeyDepartment of Obstetrics and Gynecology, Dogansehir Martyr Esra Kose Basaran State Hospital, 44500 Malatya, TurkeyDepartment of Obstetrics and Gynecology, Istanbul Training and Research Hospital, 34098 Istanbul, TurkeyDepartment of Obstetrics and Gynecology, Bossan Hospital, 27000 Gaziantep, TurkeyBackground: Hyperemesis gravidarum is a common cause of nausea and vomiting during the early gestational week. At the same time, it can also lead to an increase in liver enzyme values in patients due to or independently of underlying liver disease. This study aimed to evaluate fasting bile acid (FBA) levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total and direct bilirubin, and urine ketone levels in pregnant women diagnosed with hyperemesis gravidarum (HG). Additionally, the study sought to investigate the relationship between HG and FBA levels. The diagnosis of HG remains primarily clinical, and identifying markers for disease severity is crucial. Methods: This retrospective cohort study obtained blood samples from 50 women diagnosed with HG and 25 healthy pregnant women. Serum levels of AST, ALT, total bilirubin (TBS), direct bilirubin, urine ketones, and FBA were measured. Statistical analysis was performed using the SPSS software version 28.0. Results: FBA levels were significantly higher in pregnant women diagnosed with HG compared to the healthy control group. Additionally, FBA levels increased simultaneously with ketonuria in the patient group. Our findings suggest that FBA levels can serve as a biomarker for diagnosing HG and indicating early-stage liver damage. Unlike previous studies, our research focused on the relationship between FBA levels and HG, providing valuable insights for future studies. Conclusions: FBA levels show promise as an objective biomarker for diagnosing HG and indicating early-stage liver damage. Further research with larger cohorts is necessary to validate these findings.https://www.imrpress.com/journal/CEOG/51/9/10.31083/j.ceog5109206hyperemesis gravidarumfasting bile acidketoneliver function testbile acid |
| spellingShingle | Ayca Kubat Kucukyurt Arzu Cetin Cansel Tanrikulu Dilara Basat Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis Gravidarum Clinical and Experimental Obstetrics & Gynecology hyperemesis gravidarum fasting bile acid ketone liver function test bile acid |
| title | Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis Gravidarum |
| title_full | Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis Gravidarum |
| title_fullStr | Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis Gravidarum |
| title_full_unstemmed | Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis Gravidarum |
| title_short | Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis Gravidarum |
| title_sort | evaluation of fasting bile acid levels in pregnant women diagnosed with hyperemesis gravidarum |
| topic | hyperemesis gravidarum fasting bile acid ketone liver function test bile acid |
| url | https://www.imrpress.com/journal/CEOG/51/9/10.31083/j.ceog5109206 |
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