B Cell signaling and Immunosuppression in Geriatrics: A Review
The human immune system undergoes significant changes with age, leading to a phenomenon termed immunosenescence- A decline in immune functionality. This decline in immune function is characterized by a diminished ability to respond to novel antigens and increased susceptibility to infections. B cell...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Hammer Head Production Limited
2024-07-01
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| Series: | Sokoto Journal of Medical Laboratory Science |
| Subjects: | |
| Online Access: | https://sokjmls.com.ng/index.php/SJMLS/article/view/531 |
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| Summary: | The human immune system undergoes significant changes with age, leading to a phenomenon termed immunosenescence- A decline in immune functionality. This decline in immune function is characterized by a diminished ability to respond to novel antigens and increased susceptibility to infections. B cells, responsible for antibody production and humoral immunity, are particularly affected by immunosenescence. This review explores the intricate interplay between B cell signaling p a t h w a y s a n d t h e d e v e l o p m e n t o f immunosuppression in the elderly. It also discusses the alterations in B cell receptor (BCR) signaling, co-stimulatory molecules, and the influence of the inflammatory environment on B cell function. Additionally, the impact of chronic co-morbidities prevalent in geriatrics on B cell signaling was examined. Finally, the potential therapeutic strategies to rejuvenate B cell responses secondary to an enhanced vaccine efficacy in older adults was examined. |
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| ISSN: | 2536-7153 |