A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes

A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes

Metformin has been demonstrated to attenuate hyperglycaemia by modulating the gut microbiota. However, the mechanisms through which the microbiome mediates metformin monotherapy failure (MMF) are unclear. Herein, in a prospective clinical cohort study of newly diagnosed type 2 diabetes mellitus (T2D...

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Bibliographic Details
Main Authors: Manyun Chen, Yilei Peng, Yuhui Hu, Zhiqiang Kang, Ting Chen, Yulong Zhang, Xiaoping Chen, Qing Li, Zuyi Yuan, Yue Wu, Heng Xu, Gan Zhou, Tao Liu, Honghao Zhou, Chunsu Yuan, Weihua Huang, Wei Zhang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Metformin resistance
Ceramide
Mitochondrial dysfunction
Oxidative phosphorylation
Gut microbiota
Farnesoid X receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000516
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