How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis
Introduction Myocarditis is an inflammatory heart disease resulting from infections, toxic exposures or autoimmune reactions. Irrespective of the factors responsible for this disease, cytokines play an important role in regulating the immunological response involved in its development and progressio...
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| Format: | Article |
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BMJ Publishing Group
2025-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/2/e087052.full |
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| author | Romuald Wojnicz Piotr Lewandowski Maciej Baron Marcin A Rojek Marcin Goławski Karol Krystek Magdalena Żegleń Pascal Zytkiewicz Jakub Kancerek Klaudia Gabriela Lis Jakub Warecki Jakub Kufel Kamila Kuśpiel |
| author_facet | Romuald Wojnicz Piotr Lewandowski Maciej Baron Marcin A Rojek Marcin Goławski Karol Krystek Magdalena Żegleń Pascal Zytkiewicz Jakub Kancerek Klaudia Gabriela Lis Jakub Warecki Jakub Kufel Kamila Kuśpiel |
| author_sort | Romuald Wojnicz |
| collection | DOAJ |
| description | Introduction Myocarditis is an inflammatory heart disease resulting from infections, toxic exposures or autoimmune reactions. Irrespective of the factors responsible for this disease, cytokines play an important role in regulating the immunological response involved in its development and progression. Accordingly, this protocol aims to conduct a systematic review and meta-analysis summarising previous research on serum and plasma levels of cytokines in patients with myocarditis and inflammatory dilated cardiomyopathy.Methods and analysis Four scientific databases: PubMed, Embase, Scopus and Web of Science, will be searched. The estimated date of the search will be 30 March 2024. Each stage of the review, including the study selection, data extraction, risk of bias and quality of evidence assessments, will be performed in duplicate. Studies meeting the following criteria will be eligible for inclusion: (1) studies involving ‘myocarditis’ or ‘inflammatory dilated cardiomyopathy’ and (2) studies are required to report serum levels of any cytokine. Meta-analyses will be used to summarise serum levels of each cytokine if possible. Subgroup analysis will be stratified by age, sex, sample size, New York Heart Association scale, cardiac Troponin T, N-terminal prohormone of brain natriuretic peptide, C reactive protein, number of lymphocytes per mm2 in the endomyocardial biopsy.Ethics approval and dissemination This study does not require ethics approval. After completion, the results will be published in a peer-reviewed paper. Data generated during the study will be published in an open access repository.PROSPERO registration number CRD42024519625 |
| format | Article |
| id | doaj-art-2ae746ca99f24d6f9aba069f150059d8 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-2ae746ca99f24d6f9aba069f150059d82025-02-08T07:00:11ZengBMJ Publishing GroupBMJ Open2044-60552025-02-0115210.1136/bmjopen-2024-087052How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysisRomuald Wojnicz0Piotr Lewandowski1Maciej Baron2Marcin A Rojek3Marcin Goławski4Karol Krystek5Magdalena Żegleń6Pascal Zytkiewicz7Jakub Kancerek8Klaudia Gabriela Lis9Jakub Warecki10Jakub Kufel11Kamila Kuśpiel121 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland1 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland1 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland1 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland2 Department of Pharmacology, Medical University of Silesia, Zabrze, Poland2 Department of Pharmacology, Medical University of Silesia, Zabrze, Poland1 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland1 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland1 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland1 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland1 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland3 Department of Radiodiagnostics, Invasive Radiology and Nuclear Medicine, Department of Radiology and Nuclear Medicine, Medical University of Silesia, Zabrze, Poland1 Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, PolandIntroduction Myocarditis is an inflammatory heart disease resulting from infections, toxic exposures or autoimmune reactions. Irrespective of the factors responsible for this disease, cytokines play an important role in regulating the immunological response involved in its development and progression. Accordingly, this protocol aims to conduct a systematic review and meta-analysis summarising previous research on serum and plasma levels of cytokines in patients with myocarditis and inflammatory dilated cardiomyopathy.Methods and analysis Four scientific databases: PubMed, Embase, Scopus and Web of Science, will be searched. The estimated date of the search will be 30 March 2024. Each stage of the review, including the study selection, data extraction, risk of bias and quality of evidence assessments, will be performed in duplicate. Studies meeting the following criteria will be eligible for inclusion: (1) studies involving ‘myocarditis’ or ‘inflammatory dilated cardiomyopathy’ and (2) studies are required to report serum levels of any cytokine. Meta-analyses will be used to summarise serum levels of each cytokine if possible. Subgroup analysis will be stratified by age, sex, sample size, New York Heart Association scale, cardiac Troponin T, N-terminal prohormone of brain natriuretic peptide, C reactive protein, number of lymphocytes per mm2 in the endomyocardial biopsy.Ethics approval and dissemination This study does not require ethics approval. After completion, the results will be published in a peer-reviewed paper. Data generated during the study will be published in an open access repository.PROSPERO registration number CRD42024519625https://bmjopen.bmj.com/content/15/2/e087052.full |
| spellingShingle | Romuald Wojnicz Piotr Lewandowski Maciej Baron Marcin A Rojek Marcin Goławski Karol Krystek Magdalena Żegleń Pascal Zytkiewicz Jakub Kancerek Klaudia Gabriela Lis Jakub Warecki Jakub Kufel Kamila Kuśpiel How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis BMJ Open |
| title | How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis |
| title_full | How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis |
| title_fullStr | How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis |
| title_full_unstemmed | How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis |
| title_short | How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis |
| title_sort | how do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals a protocol for a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/15/2/e087052.full |
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