The Endocannabinoid System as a Therapeutic Target in Glaucoma
Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attract...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/9364091 |
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| author | Elizabeth A. Cairns William H. Baldridge Melanie E. M. Kelly |
| author_facet | Elizabeth A. Cairns William H. Baldridge Melanie E. M. Kelly |
| author_sort | Elizabeth A. Cairns |
| collection | DOAJ |
| description | Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable attention as a potential target for the treatment of glaucoma, largely due to the observed IOP lowering effects seen after administration of exogenous cannabinoids. However, recent evidence has suggested that modulation of the ECS may also be neuroprotective. This paper will review the use of cannabinoids in glaucoma, presenting pertinent information regarding the pathophysiology of glaucoma and how alterations in cannabinoid signalling may contribute to glaucoma pathology. Additionally, the mechanisms and potential for the use of cannabinoids and other novel agents that target the endocannabinoid system in the treatment of glaucoma will be discussed. |
| format | Article |
| id | doaj-art-2adbc9b901a7423992bd3e1ed80f80d4 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2adbc9b901a7423992bd3e1ed80f80d42025-08-20T03:54:42ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/93640919364091The Endocannabinoid System as a Therapeutic Target in GlaucomaElizabeth A. Cairns0William H. Baldridge1Melanie E. M. Kelly2Department of Pharmacology, Dalhousie University, Halifax, NS, B3H 4R2, CanadaDepartment of Medical Neuroscience, Dalhousie University, Halifax, NS, B3H 4R2, CanadaDepartment of Pharmacology, Dalhousie University, Halifax, NS, B3H 4R2, CanadaGlaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable attention as a potential target for the treatment of glaucoma, largely due to the observed IOP lowering effects seen after administration of exogenous cannabinoids. However, recent evidence has suggested that modulation of the ECS may also be neuroprotective. This paper will review the use of cannabinoids in glaucoma, presenting pertinent information regarding the pathophysiology of glaucoma and how alterations in cannabinoid signalling may contribute to glaucoma pathology. Additionally, the mechanisms and potential for the use of cannabinoids and other novel agents that target the endocannabinoid system in the treatment of glaucoma will be discussed.http://dx.doi.org/10.1155/2016/9364091 |
| spellingShingle | Elizabeth A. Cairns William H. Baldridge Melanie E. M. Kelly The Endocannabinoid System as a Therapeutic Target in Glaucoma Neural Plasticity |
| title | The Endocannabinoid System as a Therapeutic Target in Glaucoma |
| title_full | The Endocannabinoid System as a Therapeutic Target in Glaucoma |
| title_fullStr | The Endocannabinoid System as a Therapeutic Target in Glaucoma |
| title_full_unstemmed | The Endocannabinoid System as a Therapeutic Target in Glaucoma |
| title_short | The Endocannabinoid System as a Therapeutic Target in Glaucoma |
| title_sort | endocannabinoid system as a therapeutic target in glaucoma |
| url | http://dx.doi.org/10.1155/2016/9364091 |
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