Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors
An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs). To evaluate microbial translocation in HIV, we as...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/7471380 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849307629178847232 |
|---|---|
| author | Lei Huang Jianning Deng Ren Lang Guoyang Liao Wei Jiang |
| author_facet | Lei Huang Jianning Deng Ren Lang Guoyang Liao Wei Jiang |
| author_sort | Lei Huang |
| collection | DOAJ |
| description | An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs). To evaluate microbial translocation in HIV, we assessed lipopolysaccharide (LPS) immunohistochemistry staining in lymph nodes. We found enriched bacterial LPS immunohistochemistry staining in the germinal center of a lymph node from an HIV-infected LTNP, evenly distributed from three progressors with impaired germinal center structures and rarely detected from two HIV-negative individuals. The impaired germinal center structures were consistent with collagen deposition in lymph nodes using immunohistochemistry staining. These results suggest greater immune responses against bacterial LPS translocation in LTNPs, which may reveal an important mechanism in controlling microbial translocation and disease progression in HIV LTNPs. |
| format | Article |
| id | doaj-art-2ada0946968b4341be0ea3ec02e14de4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2ada0946968b4341be0ea3ec02e14de42025-08-20T03:54:42ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/74713807471380Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from ProgressorsLei Huang0Jianning Deng1Ren Lang2Guoyang Liao3Wei Jiang4Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, ChinaDepartment of Tuberculosis, The Fourth People’s Hospital of Nanning, Nanning, Guangxi, 530023, ChinaDepartment of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, ChinaChief of No. 5 Biologicals Department, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kuming, 650118, ChinaDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, 29425, USAAn increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs). To evaluate microbial translocation in HIV, we assessed lipopolysaccharide (LPS) immunohistochemistry staining in lymph nodes. We found enriched bacterial LPS immunohistochemistry staining in the germinal center of a lymph node from an HIV-infected LTNP, evenly distributed from three progressors with impaired germinal center structures and rarely detected from two HIV-negative individuals. The impaired germinal center structures were consistent with collagen deposition in lymph nodes using immunohistochemistry staining. These results suggest greater immune responses against bacterial LPS translocation in LTNPs, which may reveal an important mechanism in controlling microbial translocation and disease progression in HIV LTNPs.http://dx.doi.org/10.1155/2020/7471380 |
| spellingShingle | Lei Huang Jianning Deng Ren Lang Guoyang Liao Wei Jiang Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors Journal of Immunology Research |
| title | Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors |
| title_full | Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors |
| title_fullStr | Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors |
| title_full_unstemmed | Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors |
| title_short | Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors |
| title_sort | enriched lps staining within the germinal center of a lymph node from an hiv infected long term nonprogressor but not from progressors |
| url | http://dx.doi.org/10.1155/2020/7471380 |
| work_keys_str_mv | AT leihuang enrichedlpsstainingwithinthegerminalcenterofalymphnodefromanhivinfectedlongtermnonprogressorbutnotfromprogressors AT jianningdeng enrichedlpsstainingwithinthegerminalcenterofalymphnodefromanhivinfectedlongtermnonprogressorbutnotfromprogressors AT renlang enrichedlpsstainingwithinthegerminalcenterofalymphnodefromanhivinfectedlongtermnonprogressorbutnotfromprogressors AT guoyangliao enrichedlpsstainingwithinthegerminalcenterofalymphnodefromanhivinfectedlongtermnonprogressorbutnotfromprogressors AT weijiang enrichedlpsstainingwithinthegerminalcenterofalymphnodefromanhivinfectedlongtermnonprogressorbutnotfromprogressors |