Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice
Background:. Nevus of Hori (HN) has been primarily reported in patients of Eastern Asian descent, with a paucity of data regarding HN occurring in African patients. In this study, we report on South African patients with HN initially thought to have melasma. Objective:. To characterize the histopath...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-03-01
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| Series: | International Journal of Women's Dermatology |
| Online Access: | http://journals.lww.com/10.1097/JW9.0000000000000190 |
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| author | Frans Maruma, MBChB, DipHivMed, MMed, FCDerm, PhD Ncoza Dlova, MBChB, FCDerm, PhD Thabiso Rafaki Petrus Mofokeng, MBChB, BSc, MMed, FCP, MPhil Boitshoko Claudia Moloabi, MBChB, BSc, MMed, FCDerm |
| author_facet | Frans Maruma, MBChB, DipHivMed, MMed, FCDerm, PhD Ncoza Dlova, MBChB, FCDerm, PhD Thabiso Rafaki Petrus Mofokeng, MBChB, BSc, MMed, FCP, MPhil Boitshoko Claudia Moloabi, MBChB, BSc, MMed, FCDerm |
| author_sort | Frans Maruma, MBChB, DipHivMed, MMed, FCDerm, PhD |
| collection | DOAJ |
| description | Background:. Nevus of Hori (HN) has been primarily reported in patients of Eastern Asian descent, with a paucity of data regarding HN occurring in African patients. In this study, we report on South African patients with HN initially thought to have melasma.
Objective:. To characterize the histopathological and clinical phenotypes of HN in African patients.
Methods:. Retrospective data were collected from patients who met the inclusion criteria. These data entailed the clinical distribution, demographic data, Fitzpatrick skin phototype, and histopathologic features of African patients diagnosed with HN from a single private aesthetic center in Bloemfontein, South Africa.
Results:. Thirty patients with an average age of 49 ± 7.37 were included in this analysis. The majority of patients were female (n = 29; 96.67%), and most patients were of Fitzpatrick skin phototype V (n = 22; 73.3%). The most common clinical distribution pattern was bitemporal (76.7%), followed by the zygomatic pattern (20%), mixed type (16.7%), and finally the central forehead pattern (3.3%). Histopathologically, the dendritic cell type of melanocytes was observed in the majority of patients (n = 25; 83.3%), while spindle-shaped cells were observed in few patients (n = 7; 23.33%), and none of the patients had bipolar-type melanocytes.
Limitations:. This study has limitations inherent to small sample size and its inability to accurately generalize the findings.
Conclusion:. HN can clinically mimic melasma in African patients. The most common clinical presentation was bitemporal. To our knowledge, this study is the largest regarding the clinicopathological profile of HN in African patients and it is likely to be the first to report these compelling findings. |
| format | Article |
| id | doaj-art-2ad8f32a668e4a238a9e18009f95ed80 |
| institution | OA Journals |
| issn | 2352-6475 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | International Journal of Women's Dermatology |
| spelling | doaj-art-2ad8f32a668e4a238a9e18009f95ed802025-08-20T02:19:38ZengWolters KluwerInternational Journal of Women's Dermatology2352-64752025-03-01111e19010.1097/JW9.0000000000000190202503000-00002Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practiceFrans Maruma, MBChB, DipHivMed, MMed, FCDerm, PhD0Ncoza Dlova, MBChB, FCDerm, PhD1Thabiso Rafaki Petrus Mofokeng, MBChB, BSc, MMed, FCP, MPhil2Boitshoko Claudia Moloabi, MBChB, BSc, MMed, FCDerm3a School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africab Department of Dermatology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africaa School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africac Private Practice, Pretoria, South AfricaBackground:. Nevus of Hori (HN) has been primarily reported in patients of Eastern Asian descent, with a paucity of data regarding HN occurring in African patients. In this study, we report on South African patients with HN initially thought to have melasma. Objective:. To characterize the histopathological and clinical phenotypes of HN in African patients. Methods:. Retrospective data were collected from patients who met the inclusion criteria. These data entailed the clinical distribution, demographic data, Fitzpatrick skin phototype, and histopathologic features of African patients diagnosed with HN from a single private aesthetic center in Bloemfontein, South Africa. Results:. Thirty patients with an average age of 49 ± 7.37 were included in this analysis. The majority of patients were female (n = 29; 96.67%), and most patients were of Fitzpatrick skin phototype V (n = 22; 73.3%). The most common clinical distribution pattern was bitemporal (76.7%), followed by the zygomatic pattern (20%), mixed type (16.7%), and finally the central forehead pattern (3.3%). Histopathologically, the dendritic cell type of melanocytes was observed in the majority of patients (n = 25; 83.3%), while spindle-shaped cells were observed in few patients (n = 7; 23.33%), and none of the patients had bipolar-type melanocytes. Limitations:. This study has limitations inherent to small sample size and its inability to accurately generalize the findings. Conclusion:. HN can clinically mimic melasma in African patients. The most common clinical presentation was bitemporal. To our knowledge, this study is the largest regarding the clinicopathological profile of HN in African patients and it is likely to be the first to report these compelling findings.http://journals.lww.com/10.1097/JW9.0000000000000190 |
| spellingShingle | Frans Maruma, MBChB, DipHivMed, MMed, FCDerm, PhD Ncoza Dlova, MBChB, FCDerm, PhD Thabiso Rafaki Petrus Mofokeng, MBChB, BSc, MMed, FCP, MPhil Boitshoko Claudia Moloabi, MBChB, BSc, MMed, FCDerm Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice International Journal of Women's Dermatology |
| title | Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice |
| title_full | Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice |
| title_fullStr | Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice |
| title_full_unstemmed | Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice |
| title_short | Nevus of Hori in African patients: an entity that is most likely underdiagnosed in clinical practice |
| title_sort | nevus of hori in african patients an entity that is most likely underdiagnosed in clinical practice |
| url | http://journals.lww.com/10.1097/JW9.0000000000000190 |
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