The performance of shear wave elastography on evaluating liver changes in obese and overweight children
Background. Real time shear-wave elastography (SWE) is a non-invasive imaging method which can quantitatively assess liver stiffness. Obesity and its complication are increasing with improving lifestyles in our century. We evaluated the performance of SWE for detecting liver changes (fatty li...
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Hacettepe University Institute of Child Health
2021-08-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/335 |
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| author | Neslihan Özkul Sağlam Sema Aksoy Selcen Yaroğlu Kazancı Figen Palabıyık Sadık Sami Hatipoğlu Ercan İnci |
| author_facet | Neslihan Özkul Sağlam Sema Aksoy Selcen Yaroğlu Kazancı Figen Palabıyık Sadık Sami Hatipoğlu Ercan İnci |
| author_sort | Neslihan Özkul Sağlam |
| collection | DOAJ |
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Background. Real time shear-wave elastography (SWE) is a non-invasive imaging method which can quantitatively assess liver stiffness. Obesity and its complication are increasing with improving lifestyles in our century. We evaluated the performance of SWE for detecting liver changes (fatty liver, steatohepatitis) in obese and overweight children, in addition to this, we determined the diagnostic accuracy and clinical usefulness of SWE in non-alcoholic fatty liver disease (NAFLD).
Methods. Obese and overweight 41 children within the age range of 6-15 years were included in this singlecenter prospective study. Biochemical evaluation for aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), total cholesterol (TC) levels, as well as conventional ultrasound and SWE of the liver were performed in the patient group. These values were compared with values of 25 normal weight and healthy children in the age range of 6-16 years.
Results. The mean SWE values was 13.7 ± 5.5 kiloPascal (kPa) and 2.03 ± 0.35 meter/second (m/s) in patient group and 7.99 ± 2.81 kPa and 1.62 ± 0.21 m/s in control group (p < 0.01). The receiver-operating characteristics (ROC) analysis was performed to determine the optimum cut-off value for elastography values (kPa) to evaluate liver changes; area under the curve was 87.5% (95% CI 79.3-95.8). When the cutoff value was set as 10.45 kPa, the sensitivity and the specificity was 69.2% and 100%, respectively. We could not observe a statistically significant difference when we compared the elastography values (kPa and m/s) according to presence of hepatosteatosis (p=0.581 and 0.172). There were no significant correlations between SWE and AST, ALT values.
Conclusions. SWE may be a useful and accurate imaging method to evaluate liver changes and monitor NAFLD in obese and overweight children.
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| format | Article |
| id | doaj-art-2acf5e4072b4426baee463aae8c67ce6 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-2acf5e4072b4426baee463aae8c67ce62025-08-20T02:55:41ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212021-08-0163410.24953/turkjped.2021.04.004The performance of shear wave elastography on evaluating liver changes in obese and overweight childrenNeslihan Özkul Sağlam0Sema Aksoy1Selcen Yaroğlu Kazancı2Figen Palabıyık3Sadık Sami Hatipoğlu4Ercan İnci5Division of General Pediatrics, Department of Pediatrics, Bakirkoy Dr Sadi Konuk Training and Research Hospital, İstanbul, Turkey.Department of Radiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, İstanbul, Turkey.Division of General Pediatrics, Department of Pediatrics, Bakirkoy Dr Sadi Konuk Training and Research Hospital, İstanbul, Turkey.Department of Radiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, İstanbul, Turkey.Division of General Pediatrics, Department of Pediatrics, Bakirkoy Dr Sadi Konuk Training and Research Hospital, İstanbul, Turkey.Department of Radiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, İstanbul, Turkey. Background. Real time shear-wave elastography (SWE) is a non-invasive imaging method which can quantitatively assess liver stiffness. Obesity and its complication are increasing with improving lifestyles in our century. We evaluated the performance of SWE for detecting liver changes (fatty liver, steatohepatitis) in obese and overweight children, in addition to this, we determined the diagnostic accuracy and clinical usefulness of SWE in non-alcoholic fatty liver disease (NAFLD). Methods. Obese and overweight 41 children within the age range of 6-15 years were included in this singlecenter prospective study. Biochemical evaluation for aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), total cholesterol (TC) levels, as well as conventional ultrasound and SWE of the liver were performed in the patient group. These values were compared with values of 25 normal weight and healthy children in the age range of 6-16 years. Results. The mean SWE values was 13.7 ± 5.5 kiloPascal (kPa) and 2.03 ± 0.35 meter/second (m/s) in patient group and 7.99 ± 2.81 kPa and 1.62 ± 0.21 m/s in control group (p < 0.01). The receiver-operating characteristics (ROC) analysis was performed to determine the optimum cut-off value for elastography values (kPa) to evaluate liver changes; area under the curve was 87.5% (95% CI 79.3-95.8). When the cutoff value was set as 10.45 kPa, the sensitivity and the specificity was 69.2% and 100%, respectively. We could not observe a statistically significant difference when we compared the elastography values (kPa and m/s) according to presence of hepatosteatosis (p=0.581 and 0.172). There were no significant correlations between SWE and AST, ALT values. Conclusions. SWE may be a useful and accurate imaging method to evaluate liver changes and monitor NAFLD in obese and overweight children. https://turkjpediatr.org/article/view/335childliverobesityreal time shear-wave elastography |
| spellingShingle | Neslihan Özkul Sağlam Sema Aksoy Selcen Yaroğlu Kazancı Figen Palabıyık Sadık Sami Hatipoğlu Ercan İnci The performance of shear wave elastography on evaluating liver changes in obese and overweight children The Turkish Journal of Pediatrics child liver obesity real time shear-wave elastography |
| title | The performance of shear wave elastography on evaluating liver changes in obese and overweight children |
| title_full | The performance of shear wave elastography on evaluating liver changes in obese and overweight children |
| title_fullStr | The performance of shear wave elastography on evaluating liver changes in obese and overweight children |
| title_full_unstemmed | The performance of shear wave elastography on evaluating liver changes in obese and overweight children |
| title_short | The performance of shear wave elastography on evaluating liver changes in obese and overweight children |
| title_sort | performance of shear wave elastography on evaluating liver changes in obese and overweight children |
| topic | child liver obesity real time shear-wave elastography |
| url | https://turkjpediatr.org/article/view/335 |
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