Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection
IntroductionChanges in the gut microbiome have been associated with the development of acute respiratory infection (ARI). However, due to methodological limitations, our knowledge of the gut virome in patients with ARIs remains limited.MethodsIn this study, fecal samples from children with ARI were...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1564755/full |
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| author | Pan Xu Chunduo Pan Minli Yuan Ying Zhu Shanjie Wei Hongyan Lu Wen Zhang |
| author_facet | Pan Xu Chunduo Pan Minli Yuan Ying Zhu Shanjie Wei Hongyan Lu Wen Zhang |
| author_sort | Pan Xu |
| collection | DOAJ |
| description | IntroductionChanges in the gut microbiome have been associated with the development of acute respiratory infection (ARI). However, due to methodological limitations, our knowledge of the gut virome in patients with ARIs remains limited.MethodsIn this study, fecal samples from children with ARI were investigated using viral metagenomics.ResultsThe fecal virome was analyzed, and several suspected disease-causing viruses were identified. The five viral families with the highest abundance of sequence reads were Podoviridae, Virgaviridae, Siphoviridae, Microviridae, and Myoviridae. Additionally, human adenovirus, human bocavirus, human astrovirus, norovirus, and human rhinovirus were detected. The genome sequences of these viruses were respectively described, and phylogenetic trees were constructed using the gene sequences of the viruses.DiscussionWe characterized the composition of gut virome in children with acute respiratory infections. However, further research is required to elucidate the relationship between acute respiratory infection and gut viruses. |
| format | Article |
| id | doaj-art-2ac8baedc50246bea79308642d40df56 |
| institution | OA Journals |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-2ac8baedc50246bea79308642d40df562025-08-20T01:54:18ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-04-011610.3389/fmicb.2025.15647551564755Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infectionPan Xu0Chunduo Pan1Minli Yuan2Ying Zhu3Shanjie Wei4Hongyan Lu5Wen Zhang6Department of Pediatrics, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Pediatrics, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Pediatrics, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Pediatrics, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Pediatrics, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Pediatrics, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaIntroductionChanges in the gut microbiome have been associated with the development of acute respiratory infection (ARI). However, due to methodological limitations, our knowledge of the gut virome in patients with ARIs remains limited.MethodsIn this study, fecal samples from children with ARI were investigated using viral metagenomics.ResultsThe fecal virome was analyzed, and several suspected disease-causing viruses were identified. The five viral families with the highest abundance of sequence reads were Podoviridae, Virgaviridae, Siphoviridae, Microviridae, and Myoviridae. Additionally, human adenovirus, human bocavirus, human astrovirus, norovirus, and human rhinovirus were detected. The genome sequences of these viruses were respectively described, and phylogenetic trees were constructed using the gene sequences of the viruses.DiscussionWe characterized the composition of gut virome in children with acute respiratory infections. However, further research is required to elucidate the relationship between acute respiratory infection and gut viruses.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1564755/fullacute respiratory infectionchildrenviral metagenomicsfecal samplesvirus evolution |
| spellingShingle | Pan Xu Chunduo Pan Minli Yuan Ying Zhu Shanjie Wei Hongyan Lu Wen Zhang Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection Frontiers in Microbiology acute respiratory infection children viral metagenomics fecal samples virus evolution |
| title | Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection |
| title_full | Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection |
| title_fullStr | Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection |
| title_full_unstemmed | Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection |
| title_short | Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection |
| title_sort | viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection |
| topic | acute respiratory infection children viral metagenomics fecal samples virus evolution |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1564755/full |
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