ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling

ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling

Background & Aims: The extracellular matrix protein 1 (ECM1) is essential for liver homeostasis by keeping latent transforming growth factor-beta quiescent. Upon hepatocyte damage, ECM1 is significantly downregulated, facilitating fibrosis and chronic liver disease (CLD) progression. We inve...

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Main Authors: Yujia Li, Chenjun Huang, Weiguo Fan, Seddik Hammad, Cyrill Géraud, Lea Berger, Shanshan Wang, Ye Yao, Chenhao Tong, Claudia Rubie, Laura Kim Feiner, Zeribe C. Nwosu, Frederik Link, Pia Erdösi, Weronika Piorońska, Kerry Gould, Christoph Meyer, Rilu Feng, Hui Liu, Chen Shao, Bing Sun, Huiguo Ding, Roman Liebe, Matthias P.A. Ebert, Honglei Weng, Matthias Glanemann, Chunfang Gao, Peter ten Dijke, Steven Dooley, Sai Wang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JHEP Reports
Subjects:
Extracellular matrix
Growth factor
IFNγ
TGF-β
Liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925001004
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