Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review
IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6936727 |
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| author | Ilaria Puxeddu Riccardo Capecchi Filippo Carta Antonio Gaetano Tavoni Paola Migliorini Roberto Puxeddu |
| author_facet | Ilaria Puxeddu Riccardo Capecchi Filippo Carta Antonio Gaetano Tavoni Paola Migliorini Roberto Puxeddu |
| author_sort | Ilaria Puxeddu |
| collection | DOAJ |
| description | IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected and clinical, serological, and histological findings can be heterogeneous. In IgG4-RD, the involvement of salivary glands is observed in 27% to 53% of patients. Several organ-specific conditions, now recognized as different manifestations of IgG4-related sialadenitis (IgG4-RS), were viewed in the past as individual disease entities. The study of salivary glands may sometimes be complex, because of the number of pathological conditions that may affect them, often with overlapping clinical pictures. Integration of different imaging techniques is often required in the case of swelling of salivary glands, even though biopsy remains the gold standard for a definite diagnosis of IgG4-RS. Thus, in this review, we discuss new insights in the pathogenesis of IgG4-RD, focusing on its clinical aspects and the tools that are currently available for a correct differential diagnosis when the salivary glands are involved. |
| format | Article |
| id | doaj-art-2ac171d835aa49ec954ee6fde9b1f766 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2ac171d835aa49ec954ee6fde9b1f7662025-08-20T03:54:42ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/69367276936727Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive ReviewIlaria Puxeddu0Riccardo Capecchi1Filippo Carta2Antonio Gaetano Tavoni3Paola Migliorini4Roberto Puxeddu5Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyClinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyOtorhinolaryngology Unit, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Cagliari, ItalyClinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyClinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyOtorhinolaryngology Unit, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Cagliari, ItalyIgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected and clinical, serological, and histological findings can be heterogeneous. In IgG4-RD, the involvement of salivary glands is observed in 27% to 53% of patients. Several organ-specific conditions, now recognized as different manifestations of IgG4-related sialadenitis (IgG4-RS), were viewed in the past as individual disease entities. The study of salivary glands may sometimes be complex, because of the number of pathological conditions that may affect them, often with overlapping clinical pictures. Integration of different imaging techniques is often required in the case of swelling of salivary glands, even though biopsy remains the gold standard for a definite diagnosis of IgG4-RS. Thus, in this review, we discuss new insights in the pathogenesis of IgG4-RD, focusing on its clinical aspects and the tools that are currently available for a correct differential diagnosis when the salivary glands are involved.http://dx.doi.org/10.1155/2018/6936727 |
| spellingShingle | Ilaria Puxeddu Riccardo Capecchi Filippo Carta Antonio Gaetano Tavoni Paola Migliorini Roberto Puxeddu Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review Journal of Immunology Research |
| title | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
| title_full | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
| title_fullStr | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
| title_full_unstemmed | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
| title_short | Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review |
| title_sort | salivary gland pathology in igg4 related disease a comprehensive review |
| url | http://dx.doi.org/10.1155/2018/6936727 |
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