Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis
Mild cognitive impairment (MCI) can be the initial manifestation of autoimmune limbic encephalitis (ALE), a disorder that at times presents a diagnostic challenge. In addition to memory impairment, clinical features that might suggest this disorder include personality changes, agitation, insomnia, a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/7247235 |
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| _version_ | 1849307616873807872 |
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| author | Robert Gross Jennifer Davis Julie Roth Henry Querfurth |
| author_facet | Robert Gross Jennifer Davis Julie Roth Henry Querfurth |
| author_sort | Robert Gross |
| collection | DOAJ |
| description | Mild cognitive impairment (MCI) can be the initial manifestation of autoimmune limbic encephalitis (ALE), a disorder that at times presents a diagnostic challenge. In addition to memory impairment, clinical features that might suggest this disorder include personality changes, agitation, insomnia, alterations of consciousness, and seizures. Once recognized, ALE typically responds to treatment with immune therapies, but long-term cognitive deficits may remain. We report two cases of patients with MCI who were ultimately diagnosed with ALE with antibodies against the voltage gated potassium channel complex. Months after apparent resolution of their encephalitides, both underwent neuropsychological testing, which demonstrated persistent cognitive deficits, primarily in the domains of memory and executive function, for cases 1 and 2, respectively. A brief review of the literature is included. |
| format | Article |
| id | doaj-art-2abb554ed24e4ea79c5f81fdaf501a74 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-2abb554ed24e4ea79c5f81fdaf501a742025-08-20T03:54:42ZengWileyCase Reports in Neurological Medicine2090-66682090-66762016-01-01201610.1155/2016/72472357247235Cognitive Impairments Preceding and Outlasting Autoimmune Limbic EncephalitisRobert Gross0Jennifer Davis1Julie Roth2Henry Querfurth3Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Psychiatry, Rhode Island Hospital, Brown University School of Medicine, Providence, RI 02903, USADepartment of Neurology, Rhode Island Hospital, Brown University School of Medicine, Providence, RI 02903, USADepartment of Neurology, Rhode Island Hospital, Brown University School of Medicine, Providence, RI 02903, USAMild cognitive impairment (MCI) can be the initial manifestation of autoimmune limbic encephalitis (ALE), a disorder that at times presents a diagnostic challenge. In addition to memory impairment, clinical features that might suggest this disorder include personality changes, agitation, insomnia, alterations of consciousness, and seizures. Once recognized, ALE typically responds to treatment with immune therapies, but long-term cognitive deficits may remain. We report two cases of patients with MCI who were ultimately diagnosed with ALE with antibodies against the voltage gated potassium channel complex. Months after apparent resolution of their encephalitides, both underwent neuropsychological testing, which demonstrated persistent cognitive deficits, primarily in the domains of memory and executive function, for cases 1 and 2, respectively. A brief review of the literature is included.http://dx.doi.org/10.1155/2016/7247235 |
| spellingShingle | Robert Gross Jennifer Davis Julie Roth Henry Querfurth Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis Case Reports in Neurological Medicine |
| title | Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis |
| title_full | Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis |
| title_fullStr | Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis |
| title_full_unstemmed | Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis |
| title_short | Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis |
| title_sort | cognitive impairments preceding and outlasting autoimmune limbic encephalitis |
| url | http://dx.doi.org/10.1155/2016/7247235 |
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