MACL-1 Breast Cancer Secretome Reprograms Fibroblasts to Enhance Inflammation and Tumor Progression

MACL-1 Breast Cancer Secretome Reprograms Fibroblasts to Enhance Inflammation and Tumor Progression

Abstract Tumor-secreted factors reprogram the stromal microenvironment to facilitate cancer progression. This study investigates the effects of the MACL-1 breast cancer cell secretome on CCD19-Lu fibroblasts. Fibroblasts treated with the MACL-1 secretome exhibited increased proliferation, altered mo...

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Bibliographic Details
Main Authors: RODRIGO JUNIO R. BARROS, ANDREIA LAURA P. RODRIGUES, CAMILA DOURADO, LUCIANA MARIA SILVA, JONAS ENRIQUE A. PERALES, SANDRA LAUTON-SANTOS, ANDREIA BARROSO, JADER S. CRUZ
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2025-08-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
Breast cancer
MACL-1 cells
CCD19-Lu fibroblasts
Vimentin
Oxidative stress
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000300605&lng=en&tlng=en
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