Metabolic dysregulation and resistance to high-fat diet-induced weight gain in mice overexpressing human wild-type α-synuclein

Abstract Unintentional weight loss is common among patients with Parkinson’s disease (PD) and is associated with poor quality of life and accelerated disease progression. To explore how early α-synuclein pathology contributes to metabolic dysregulation leading to weight loss in PD, transgenic mice o...

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Bibliographic Details
Main Authors: K. C. Biju, Enrique Torres Hernandez, Alison Michelle Stallings, Ada C. Felix-Ortiz, Skanda K. Hebbale, Luke Norton, Michael J. Mader, Robert A. Clark
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00961-w
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