NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

Abstract DNA methylation regulators play critical roles in modulating oncogenic driver genes in cancers. However, the precise mechanisms through which these DNA methylation regulators influence oncogenesis and clinical therapy have yet to be fully elucidated. This study reveals that hypermethylation...

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Main Authors: Xukun Li, Dandan Fan, Yong Li, Jian Yuan, Wanyuan Sun, Qinghao Zhu, Ling Qi, Xueling Wu, Jiahui Cai, Tongyang Gong, Ning Zhao, Jianzhong Su, Zhihua Liu, Hongyan Chen
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
DNA methylation
LHX1
NKX2‐5
transcriptional dysregulation
UHRF1
Online Access:https://doi.org/10.1002/advs.202413508
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