Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats
Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function rest...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/6928489 |
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| author | Mira Chamoun Elena G. Sergeeva Petra Henrich-Noack Shaobo Jia Lisa Grigartzik Jing Ma Qing You Frédéric Huppé-Gourgues Bernhard A. Sabel Elvire Vaucher |
| author_facet | Mira Chamoun Elena G. Sergeeva Petra Henrich-Noack Shaobo Jia Lisa Grigartzik Jing Ma Qing You Frédéric Huppé-Gourgues Bernhard A. Sabel Elvire Vaucher |
| author_sort | Mira Chamoun |
| collection | DOAJ |
| description | Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration. To this end, we evaluated for 4 weeks the effect of the acetylcholinesterase inhibitor donepezil on brightness discrimination, visually evoked potentials, and visual cortex reactivity after a bilateral and partial optic nerve crush in adult rats. Donepezil administration enhanced brightness discrimination capacity after optic nerve crush compared to nontreated animals. The visually evoked activation of the primary visual cortex was not restored, as measured by evoked potentials, but the cortical neuronal activity measured by thallium autometallography was not significantly affected four weeks after the optic nerve crush. Altogether, the results suggest a role of the cholinergic system in postlesion cortical plasticity. This finding agrees with the view that restoration of visual function may involve mechanisms beyond the area of primary damage and opens a new perspective for improving visual rehabilitation in humans. |
| format | Article |
| id | doaj-art-2aa4dade5e164469bee6c89911f9d29f |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2aa4dade5e164469bee6c89911f9d29f2025-02-03T06:01:23ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/69284896928489Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in RatsMira Chamoun0Elena G. Sergeeva1Petra Henrich-Noack2Shaobo Jia3Lisa Grigartzik4Jing Ma5Qing You6Frédéric Huppé-Gourgues7Bernhard A. Sabel8Elvire Vaucher9Laboratoire de Neurobiologie de la Cognition Visuelle, École d'optométrie, Université de Montréal, Montréal, QC, CanadaInstitute of Medical Psychology, Otto von Guericke University, Magdeburg, GermanyInstitute of Medical Psychology, Otto von Guericke University, Magdeburg, GermanyInstitute of Medical Psychology, Otto von Guericke University, Magdeburg, GermanyInstitute of Medical Psychology, Otto von Guericke University, Magdeburg, GermanyInstitute of Medical Psychology, Otto von Guericke University, Magdeburg, GermanyInstitute of Medical Psychology, Otto von Guericke University, Magdeburg, GermanyLaboratoire de Neurobiologie de la Cognition Visuelle, École d'optométrie, Université de Montréal, Montréal, QC, CanadaInstitute of Medical Psychology, Otto von Guericke University, Magdeburg, GermanyLaboratoire de Neurobiologie de la Cognition Visuelle, École d'optométrie, Université de Montréal, Montréal, QC, CanadaEnhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration. To this end, we evaluated for 4 weeks the effect of the acetylcholinesterase inhibitor donepezil on brightness discrimination, visually evoked potentials, and visual cortex reactivity after a bilateral and partial optic nerve crush in adult rats. Donepezil administration enhanced brightness discrimination capacity after optic nerve crush compared to nontreated animals. The visually evoked activation of the primary visual cortex was not restored, as measured by evoked potentials, but the cortical neuronal activity measured by thallium autometallography was not significantly affected four weeks after the optic nerve crush. Altogether, the results suggest a role of the cholinergic system in postlesion cortical plasticity. This finding agrees with the view that restoration of visual function may involve mechanisms beyond the area of primary damage and opens a new perspective for improving visual rehabilitation in humans.http://dx.doi.org/10.1155/2017/6928489 |
| spellingShingle | Mira Chamoun Elena G. Sergeeva Petra Henrich-Noack Shaobo Jia Lisa Grigartzik Jing Ma Qing You Frédéric Huppé-Gourgues Bernhard A. Sabel Elvire Vaucher Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats Neural Plasticity |
| title | Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats |
| title_full | Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats |
| title_fullStr | Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats |
| title_full_unstemmed | Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats |
| title_short | Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats |
| title_sort | cholinergic potentiation of restoration of visual function after optic nerve damage in rats |
| url | http://dx.doi.org/10.1155/2017/6928489 |
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