Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study
BackgroundWHO grade II oligodendroglioma (OG/II) is a rare primary brain tumor with various outcomes. Our study aims to investigate prognostic factors for postoperative OG/II patients and then evaluate the instructional value of tumor size.MethodsWe retrospectively studied the cases from the Surveil...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2025.1455567/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548251157397504 |
|---|---|
| author | Qin Lu Yongyan Wu Yonglin Xie Shuxu Yang Hongchuan Jin |
| author_facet | Qin Lu Yongyan Wu Yonglin Xie Shuxu Yang Hongchuan Jin |
| author_sort | Qin Lu |
| collection | DOAJ |
| description | BackgroundWHO grade II oligodendroglioma (OG/II) is a rare primary brain tumor with various outcomes. Our study aims to investigate prognostic factors for postoperative OG/II patients and then evaluate the instructional value of tumor size.MethodsWe retrospectively studied the cases from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox analyses and Kaplan-Meier survival curves were used to identify and assess prognostic factors. The optimal cut-off value of tumor size was determined by X-tile analysis and verified by multivariate analyses. Subsequently, Subgroup analyses were performed based on tumor size.Result676 OG/II patients were enrolled in our study. Multivariate Cox analyses revealed that age > 60 (HR 3.52), male (HR 1.48), total resection (HR 0.38), and tumor size (HR 2.04) were independent factors in predicting cancer-specific survival (CCS). The optimal cut-off value for tumor size was 60 mm. Patients with tumor size less than 60 mm, age > 60 (HR 3.82), and radiation (HR 1.58) were associated with worse CSS, while total resection (HR 0.35) was associated with better CSS. Lastly, a tumor size-based nomogram was established objectively and accurately.ConclusionOur study identified four crucial prognostic factors related to CSS in postoperative OG/II patients: age, sex, the extent of recession, and tumor size. A tumor size of 60 mm was an optimal cut-off point for dividing patients into low and high-risk groups. Patients in the low-risk group may not benefit from extended resection and radiation. Tumor size can be a valuable factor for making therapeutic schedules. |
| format | Article |
| id | doaj-art-2aa364b6fc7a484e9f2576a8ecfa39d6 |
| institution | Kabale University |
| issn | 2296-875X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj-art-2aa364b6fc7a484e9f2576a8ecfa39d62025-02-03T06:33:34ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2025-02-011210.3389/fsurg.2025.14555671455567Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based studyQin Lu0Yongyan Wu1Yonglin Xie2Shuxu Yang3Hongchuan Jin4Department of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Emergency, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, ChinaLaboratory of Cancer Biology, Key Lab of Biotherapy, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, ChinaBackgroundWHO grade II oligodendroglioma (OG/II) is a rare primary brain tumor with various outcomes. Our study aims to investigate prognostic factors for postoperative OG/II patients and then evaluate the instructional value of tumor size.MethodsWe retrospectively studied the cases from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox analyses and Kaplan-Meier survival curves were used to identify and assess prognostic factors. The optimal cut-off value of tumor size was determined by X-tile analysis and verified by multivariate analyses. Subsequently, Subgroup analyses were performed based on tumor size.Result676 OG/II patients were enrolled in our study. Multivariate Cox analyses revealed that age > 60 (HR 3.52), male (HR 1.48), total resection (HR 0.38), and tumor size (HR 2.04) were independent factors in predicting cancer-specific survival (CCS). The optimal cut-off value for tumor size was 60 mm. Patients with tumor size less than 60 mm, age > 60 (HR 3.82), and radiation (HR 1.58) were associated with worse CSS, while total resection (HR 0.35) was associated with better CSS. Lastly, a tumor size-based nomogram was established objectively and accurately.ConclusionOur study identified four crucial prognostic factors related to CSS in postoperative OG/II patients: age, sex, the extent of recession, and tumor size. A tumor size of 60 mm was an optimal cut-off point for dividing patients into low and high-risk groups. Patients in the low-risk group may not benefit from extended resection and radiation. Tumor size can be a valuable factor for making therapeutic schedules.https://www.frontiersin.org/articles/10.3389/fsurg.2025.1455567/fullWHO grade II oligodendrogliomaSEER databaseprognosissurvival analysistumor size |
| spellingShingle | Qin Lu Yongyan Wu Yonglin Xie Shuxu Yang Hongchuan Jin Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study Frontiers in Surgery WHO grade II oligodendroglioma SEER database prognosis survival analysis tumor size |
| title | Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study |
| title_full | Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study |
| title_fullStr | Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study |
| title_full_unstemmed | Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study |
| title_short | Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study |
| title_sort | prognostic impact of tumor size on cancer specific survival for postoperative who grade ii oligodendroglioma a seer based study |
| topic | WHO grade II oligodendroglioma SEER database prognosis survival analysis tumor size |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2025.1455567/full |
| work_keys_str_mv | AT qinlu prognosticimpactoftumorsizeoncancerspecificsurvivalforpostoperativewhogradeiioligodendrogliomaaseerbasedstudy AT yongyanwu prognosticimpactoftumorsizeoncancerspecificsurvivalforpostoperativewhogradeiioligodendrogliomaaseerbasedstudy AT yonglinxie prognosticimpactoftumorsizeoncancerspecificsurvivalforpostoperativewhogradeiioligodendrogliomaaseerbasedstudy AT shuxuyang prognosticimpactoftumorsizeoncancerspecificsurvivalforpostoperativewhogradeiioligodendrogliomaaseerbasedstudy AT hongchuanjin prognosticimpactoftumorsizeoncancerspecificsurvivalforpostoperativewhogradeiioligodendrogliomaaseerbasedstudy |