Does Heart Rate Variability Predict Impairment of Operational Performance in Divers?
We examined data from Naval Sea Systems Command grant project N0463A-12-C-001, “Hypercapnia: cognitive effects and monitoring”, with the objective of validating or repudiating heart rate variability (HRV) as a warning sign of cognitive impairment from diving gas narcosis or oxygen toxicity. We compa...
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MDPI AG
2024-12-01
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| author | John Freiberger Bruce Derrick Ki H. Chon Md Billal Hossain Hugo F. Posada-Quintero Mary Cooter Richard Moon |
| author_facet | John Freiberger Bruce Derrick Ki H. Chon Md Billal Hossain Hugo F. Posada-Quintero Mary Cooter Richard Moon |
| author_sort | John Freiberger |
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| description | We examined data from Naval Sea Systems Command grant project N0463A-12-C-001, “Hypercapnia: cognitive effects and monitoring”, with the objective of validating or repudiating heart rate variability (HRV) as a warning sign of cognitive impairment from diving gas narcosis or oxygen toxicity. We compared HRV feature scores to their temporally corresponding cognitive outcomes under normal and narcotizing conditions to identify specific HRV features associated with cognitive changes. N0463A-12-C-001 was conducted between 17 September 2013 and 29 January 2016 and employed NASA’s multi-attribute task battery (MATB-II) flight simulator to examine the independent effects of CO<sub>2</sub>, N<sub>2</sub>, and O<sub>2</sub> partial pressure on diver performance at simulated depths up to 61 msw (200 fsw). We assessed the association of 23 distinct HRV features scores from 432 of the study’s analyzable exposure stages in relation to MATB-II’s four performance subclasses (motor, memory, attention, strategy) while controlling for exercise and CO<sub>2</sub>, N<sub>2</sub>, and O<sub>2</sub> gas partial pressure. Performance decrements were associated with normalized high-frequency HRVfeatures (HFnu, <i>p</i> = 0.0016) and the number of pairs of successive R-R intervals that differed by more than 50 ms (NN50count1, <i>p</i> = 0.04). Secondary analysis with stratification restricted to non-exercise stages showed that several HRV parameters, including root mean square of the successive difference (RMSSD, <i>p</i> = 0.0015), width of Poincaré plot (<i>p</i> = 0.0017), NN50count1 (<i>p</i> = 0.0019), and standard deviation of normal-to-normal R peaks (<i>p</i> = 0.0082), were associated with performance impairment. The RMSSD association retained statistical significance after Bonferroni correction for multiple tests. HRV features collected from divers tested under narcotizing conditions of breathing gas partial pressure and exercise were associated with performance impairment. |
| format | Article |
| id | doaj-art-2aa02462bdfe4e00ab6433bf0e3b1886 |
| institution | OA Journals |
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| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-2aa02462bdfe4e00ab6433bf0e3b18862025-08-20T01:55:37ZengMDPI AGSensors1424-82202024-12-012423772610.3390/s24237726Does Heart Rate Variability Predict Impairment of Operational Performance in Divers?John Freiberger0Bruce Derrick1Ki H. Chon2Md Billal Hossain3Hugo F. Posada-Quintero4Mary Cooter5Richard Moon6Department of Anesthesiology, Duke University, Durham, NC 27708, USADepartment of Anesthesiology, Duke University, Durham, NC 27708, USADepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USADepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USADepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USASchool of Medicine, Duke University, Durham, NC 27710, USADepartment of Anesthesiology, Duke University, Durham, NC 27708, USAWe examined data from Naval Sea Systems Command grant project N0463A-12-C-001, “Hypercapnia: cognitive effects and monitoring”, with the objective of validating or repudiating heart rate variability (HRV) as a warning sign of cognitive impairment from diving gas narcosis or oxygen toxicity. We compared HRV feature scores to their temporally corresponding cognitive outcomes under normal and narcotizing conditions to identify specific HRV features associated with cognitive changes. N0463A-12-C-001 was conducted between 17 September 2013 and 29 January 2016 and employed NASA’s multi-attribute task battery (MATB-II) flight simulator to examine the independent effects of CO<sub>2</sub>, N<sub>2</sub>, and O<sub>2</sub> partial pressure on diver performance at simulated depths up to 61 msw (200 fsw). We assessed the association of 23 distinct HRV features scores from 432 of the study’s analyzable exposure stages in relation to MATB-II’s four performance subclasses (motor, memory, attention, strategy) while controlling for exercise and CO<sub>2</sub>, N<sub>2</sub>, and O<sub>2</sub> gas partial pressure. Performance decrements were associated with normalized high-frequency HRVfeatures (HFnu, <i>p</i> = 0.0016) and the number of pairs of successive R-R intervals that differed by more than 50 ms (NN50count1, <i>p</i> = 0.04). Secondary analysis with stratification restricted to non-exercise stages showed that several HRV parameters, including root mean square of the successive difference (RMSSD, <i>p</i> = 0.0015), width of Poincaré plot (<i>p</i> = 0.0017), NN50count1 (<i>p</i> = 0.0019), and standard deviation of normal-to-normal R peaks (<i>p</i> = 0.0082), were associated with performance impairment. The RMSSD association retained statistical significance after Bonferroni correction for multiple tests. HRV features collected from divers tested under narcotizing conditions of breathing gas partial pressure and exercise were associated with performance impairment.https://www.mdpi.com/1424-8220/24/23/7726heart rate variabilitydivingnarcosisnitrogencarbon dioxideoxygen toxicity |
| spellingShingle | John Freiberger Bruce Derrick Ki H. Chon Md Billal Hossain Hugo F. Posada-Quintero Mary Cooter Richard Moon Does Heart Rate Variability Predict Impairment of Operational Performance in Divers? Sensors heart rate variability diving narcosis nitrogen carbon dioxide oxygen toxicity |
| title | Does Heart Rate Variability Predict Impairment of Operational Performance in Divers? |
| title_full | Does Heart Rate Variability Predict Impairment of Operational Performance in Divers? |
| title_fullStr | Does Heart Rate Variability Predict Impairment of Operational Performance in Divers? |
| title_full_unstemmed | Does Heart Rate Variability Predict Impairment of Operational Performance in Divers? |
| title_short | Does Heart Rate Variability Predict Impairment of Operational Performance in Divers? |
| title_sort | does heart rate variability predict impairment of operational performance in divers |
| topic | heart rate variability diving narcosis nitrogen carbon dioxide oxygen toxicity |
| url | https://www.mdpi.com/1424-8220/24/23/7726 |
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