Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells
In this study, the protective functions of bacteria-free conditioned media from Bifidobacterium and Lactobacillus species against ultraviolet radiation-induced skin ageing and associated cellular damage were investigated. The effects of ultraviolet radiation-induced reactive oxygen species productio...
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| Format: | Article |
| Language: | English |
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Sciendo
2022-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2022-0027 |
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| author | Hong Yoo Kyung An Sungkwan Lee Yun Hee Yang Seung Ah Yoon Yoo Kyung Lee Joonil Lee Gwasoo Chung Myung Jun Bae Seunghee |
| author_facet | Hong Yoo Kyung An Sungkwan Lee Yun Hee Yang Seung Ah Yoon Yoo Kyung Lee Joonil Lee Gwasoo Chung Myung Jun Bae Seunghee |
| author_sort | Hong Yoo Kyung |
| collection | DOAJ |
| description | In this study, the protective functions of bacteria-free conditioned media from Bifidobacterium and Lactobacillus species against ultraviolet radiation-induced skin ageing and associated cellular damage were investigated. The effects of ultraviolet radiation-induced reactive oxygen species production were suppressed by all conditioned media; particularly, the loss of cell viability and downregulation of collagen gene expression were significantly reversed by the conditioned media from B. longum and B. lactis. Further exa mination of potential anti-pigmentation effects revealed that the B. lactis-derived conditioned media significantly inhibited tyrosinase activity and alpha-melanocyte-stimulating hormone-induced melanin production in human epidermal melanocytes. Further, the conditioned media suppressed the phosphorylation of extracellular signal- related kinase, which functions as an upstream regulator of melanogenesis. Therefore, B. lactis-derived conditioned media can potentially protect against cellular damage involved in skin-ageing processes. |
| format | Article |
| id | doaj-art-2a9b90d589a2421684d0db932a783135 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-2a9b90d589a2421684d0db932a7831352025-02-02T16:18:21ZengSciendoActa Pharmaceutica1846-95582022-09-0172335937410.2478/acph-2022-0027Potential anti-ageing effects of probiotic-derived conditioned media on human skin cellsHong Yoo Kyung0An Sungkwan1Lee Yun Hee2Yang Seung Ah3Yoon Yoo Kyung4Lee Joonil5Lee Gwasoo6Chung Myung Jun7Bae Seunghee8Research Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk UniversitySeoul05029, Republic of KoreaResearch Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk UniversitySeoul05029, Republic of KoreaResearch Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk UniversitySeoul05029, Republic of KoreaResearch Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk UniversitySeoul05029, Republic of KoreaResearch Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk UniversitySeoul05029, Republic of KoreaResearch and Development Center Cell Biotech, Co., Ltd., Gimpo10003Republic of KoreaResearch and Development Center Cell Biotech, Co., Ltd., Gimpo10003Republic of KoreaResearch and Development Center Cell Biotech, Co., Ltd., Gimpo10003Republic of KoreaResearch Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk UniversitySeoul05029, Republic of KoreaIn this study, the protective functions of bacteria-free conditioned media from Bifidobacterium and Lactobacillus species against ultraviolet radiation-induced skin ageing and associated cellular damage were investigated. The effects of ultraviolet radiation-induced reactive oxygen species production were suppressed by all conditioned media; particularly, the loss of cell viability and downregulation of collagen gene expression were significantly reversed by the conditioned media from B. longum and B. lactis. Further exa mination of potential anti-pigmentation effects revealed that the B. lactis-derived conditioned media significantly inhibited tyrosinase activity and alpha-melanocyte-stimulating hormone-induced melanin production in human epidermal melanocytes. Further, the conditioned media suppressed the phosphorylation of extracellular signal- related kinase, which functions as an upstream regulator of melanogenesis. Therefore, B. lactis-derived conditioned media can potentially protect against cellular damage involved in skin-ageing processes.https://doi.org/10.2478/acph-2022-0027anti-ageingskin cellsprobioticsconditioned mediaprotectionanti-pigmentation |
| spellingShingle | Hong Yoo Kyung An Sungkwan Lee Yun Hee Yang Seung Ah Yoon Yoo Kyung Lee Joonil Lee Gwasoo Chung Myung Jun Bae Seunghee Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells Acta Pharmaceutica anti-ageing skin cells probiotics conditioned media protection anti-pigmentation |
| title | Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells |
| title_full | Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells |
| title_fullStr | Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells |
| title_full_unstemmed | Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells |
| title_short | Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells |
| title_sort | potential anti ageing effects of probiotic derived conditioned media on human skin cells |
| topic | anti-ageing skin cells probiotics conditioned media protection anti-pigmentation |
| url | https://doi.org/10.2478/acph-2022-0027 |
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