A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism.
Mitochondria possess a remarkable ability to rapidly accumulate and sequester Ca²⁺. One of the mechanisms responsible for this ability is believed to be the rapid mode (RaM) of Ca²⁺ uptake. Despite the existence of many models of mitochondrial Ca²⁺ dynamics, very few consider RaM as a potential mech...
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021324&type=printable |
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| author | Jason N Bazil Ranjan K Dash |
| author_facet | Jason N Bazil Ranjan K Dash |
| author_sort | Jason N Bazil |
| collection | DOAJ |
| description | Mitochondria possess a remarkable ability to rapidly accumulate and sequester Ca²⁺. One of the mechanisms responsible for this ability is believed to be the rapid mode (RaM) of Ca²⁺ uptake. Despite the existence of many models of mitochondrial Ca²⁺ dynamics, very few consider RaM as a potential mechanism that regulates mitochondrial Ca²⁺ dynamics. To fill this gap, a novel mathematical model of the RaM mechanism is developed herein. The model is able to simulate the available experimental data of rapid Ca²⁺ uptake in isolated mitochondria from both chicken heart and rat liver tissues with good fidelity. The mechanism is based on Ca²⁺ binding to an external trigger site(s) and initiating a brief transient of high Ca²⁺ conductivity. It then quickly switches to an inhibited, zero-conductive state until the external Ca²⁺ level is dropped below a critical value (∼100-150 nM). RaM's Ca²⁺- and time-dependent properties make it a unique Ca²⁺ transporter that may be an important means by which mitochondria take up Ca²⁺ in situ and help enable mitochondria to decode cytosolic Ca²⁺ signals. Integrating the developed RaM model into existing models of mitochondrial Ca²⁺ dynamics will help elucidate the physiological role that this unique mechanism plays in mitochondrial Ca²⁺-homeostasis and bioenergetics. |
| format | Article |
| id | doaj-art-2a9901592da5435a936c93a67049d411 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-2a9901592da5435a936c93a67049d4112025-08-20T03:09:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0166e2132410.1371/journal.pone.0021324A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism.Jason N BazilRanjan K DashMitochondria possess a remarkable ability to rapidly accumulate and sequester Ca²⁺. One of the mechanisms responsible for this ability is believed to be the rapid mode (RaM) of Ca²⁺ uptake. Despite the existence of many models of mitochondrial Ca²⁺ dynamics, very few consider RaM as a potential mechanism that regulates mitochondrial Ca²⁺ dynamics. To fill this gap, a novel mathematical model of the RaM mechanism is developed herein. The model is able to simulate the available experimental data of rapid Ca²⁺ uptake in isolated mitochondria from both chicken heart and rat liver tissues with good fidelity. The mechanism is based on Ca²⁺ binding to an external trigger site(s) and initiating a brief transient of high Ca²⁺ conductivity. It then quickly switches to an inhibited, zero-conductive state until the external Ca²⁺ level is dropped below a critical value (∼100-150 nM). RaM's Ca²⁺- and time-dependent properties make it a unique Ca²⁺ transporter that may be an important means by which mitochondria take up Ca²⁺ in situ and help enable mitochondria to decode cytosolic Ca²⁺ signals. Integrating the developed RaM model into existing models of mitochondrial Ca²⁺ dynamics will help elucidate the physiological role that this unique mechanism plays in mitochondrial Ca²⁺-homeostasis and bioenergetics.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021324&type=printable |
| spellingShingle | Jason N Bazil Ranjan K Dash A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism. PLoS ONE |
| title | A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism. |
| title_full | A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism. |
| title_fullStr | A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism. |
| title_full_unstemmed | A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism. |
| title_short | A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism. |
| title_sort | minimal model for the mitochondrial rapid mode of ca² uptake mechanism |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021324&type=printable |
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