Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver Nanoparticles
Study’s Novelty/Excerpt • This study comprehensively review the significant advancements in the antimicrobial application of silver nanoparticles (AgNPs), focusing on innovative delivery mechanisms such as nanogels, liposomes, and polymer-based nanoparticles. • It highlights the unique physico...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Umaru Musa Yar'adua University, Katsina, Nigeria
2024-06-01
|
| Series: | UMYU Journal of Microbiology Research |
| Subjects: | |
| Online Access: | https://ujmr.umyu.edu.ng/index.php/ujmr/article/view/558 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850270471014055936 |
|---|---|
| author | Idris, N. U. Faruk, F. U. Yerima, M. I. Isa, A. K. |
| author_facet | Idris, N. U. Faruk, F. U. Yerima, M. I. Isa, A. K. |
| author_sort | Idris, N. U. |
| collection | DOAJ |
| description | Study’s Novelty/Excerpt
• This study comprehensively review the significant advancements in the antimicrobial application of silver nanoparticles (AgNPs), focusing on innovative delivery mechanisms such as nanogels, liposomes, and polymer-based nanoparticles.
• It highlights the unique physicochemical properties of AgNPs that contribute to their antibacterial efficacy, including their ability to disrupt bacterial cell membranes and inhibit biofilm formation.
• The review also addresses the critical challenges of cytotoxicity and delivery method refinement, emphasizing the potential of AgNPs in combating antibiotic-resistant bacteria.
Full Abstract
Nanoparticles,especially silver nanoparticles (AgNPs), have revolutionized various fields like microbiology, biotechnology, pharmacy, and medicine owing to their distinct properties. This research delves into the significant potential of AgNPs in antimicrobial therapy, focusing on recent advancements in their delivery mechanisms, mechanisms of action, and antibacterial efficacy. The effective targeted delivery of AgNPs to specific body sites remains a challenge, leading to innovative approaches in nanotechnology. Nanogels, liposomes, and polymer-based nanoparticles have emerged as promising delivery systems, enhancing the stability, bioavailability, and controlled release of AgNPs. The antimicrobial activity of AgNPs is rooted in their unique physicochemical properties, such as high surface area and reactivity. They disrupt bacterial cell membranes, increasing permeability, causing cell death, and interfering with intracellular components. Additionally, AgNPs have shown potential in inhibiting biofilm formation, a common defense mechanism of bacteria against antibiotics. Despite their promise, addressing issues related to cytotoxicity and refining delivery methods remains imperative. This review comprehensively addresses the challenges associated with the delivery of AgNPs, their cytotoxic effects, and their efficacy against antibiotic-resistant bacteria, highlighting their mechanism of action in bacterial eradication and biofilm inhibition. |
| format | Article |
| id | doaj-art-2a98bda2834e457cbc18f23f05ba6ef4 |
| institution | OA Journals |
| issn | 2616-0668 2814-1822 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Umaru Musa Yar'adua University, Katsina, Nigeria |
| record_format | Article |
| series | UMYU Journal of Microbiology Research |
| spelling | doaj-art-2a98bda2834e457cbc18f23f05ba6ef42025-08-20T01:52:38ZengUmaru Musa Yar'adua University, Katsina, NigeriaUMYU Journal of Microbiology Research2616-06682814-18222024-06-0110412110.47430/ujmr.2493.013558Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver NanoparticlesIdris, N. U.0https://orcid.org/0000-0001-6506-5532Faruk, F. U.1https://orcid.org/0000-0002-1220-9544Yerima, M. I.2https://orcid.org/0009-0009-1147-1151Isa, A. K.3https://orcid.org/0009-0007-0430-0843Department of Microbiology, Bauchi State University, Bauchi, NigeriaDepartment of Biological Sciences, Abubakar Tafawa Balewa University, Bauchi, NigeriaDepartment of Biological Sciences, Abubakar Tafawa Balewa University, Bauchi, NigeriaDepartment of Science Laboratory Technology, Federal Polytechnic Bauchi, Bauchi, NigeriaStudy’s Novelty/Excerpt • This study comprehensively review the significant advancements in the antimicrobial application of silver nanoparticles (AgNPs), focusing on innovative delivery mechanisms such as nanogels, liposomes, and polymer-based nanoparticles. • It highlights the unique physicochemical properties of AgNPs that contribute to their antibacterial efficacy, including their ability to disrupt bacterial cell membranes and inhibit biofilm formation. • The review also addresses the critical challenges of cytotoxicity and delivery method refinement, emphasizing the potential of AgNPs in combating antibiotic-resistant bacteria. Full Abstract Nanoparticles,especially silver nanoparticles (AgNPs), have revolutionized various fields like microbiology, biotechnology, pharmacy, and medicine owing to their distinct properties. This research delves into the significant potential of AgNPs in antimicrobial therapy, focusing on recent advancements in their delivery mechanisms, mechanisms of action, and antibacterial efficacy. The effective targeted delivery of AgNPs to specific body sites remains a challenge, leading to innovative approaches in nanotechnology. Nanogels, liposomes, and polymer-based nanoparticles have emerged as promising delivery systems, enhancing the stability, bioavailability, and controlled release of AgNPs. The antimicrobial activity of AgNPs is rooted in their unique physicochemical properties, such as high surface area and reactivity. They disrupt bacterial cell membranes, increasing permeability, causing cell death, and interfering with intracellular components. Additionally, AgNPs have shown potential in inhibiting biofilm formation, a common defense mechanism of bacteria against antibiotics. Despite their promise, addressing issues related to cytotoxicity and refining delivery methods remains imperative. This review comprehensively addresses the challenges associated with the delivery of AgNPs, their cytotoxic effects, and their efficacy against antibiotic-resistant bacteria, highlighting their mechanism of action in bacterial eradication and biofilm inhibition.https://ujmr.umyu.edu.ng/index.php/ujmr/article/view/558anti-microbial resistancedeliverymechanism of actionsilver nanoparticles |
| spellingShingle | Idris, N. U. Faruk, F. U. Yerima, M. I. Isa, A. K. Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver Nanoparticles UMYU Journal of Microbiology Research anti-microbial resistance delivery mechanism of action silver nanoparticles |
| title | Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver Nanoparticles |
| title_full | Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver Nanoparticles |
| title_fullStr | Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver Nanoparticles |
| title_full_unstemmed | Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver Nanoparticles |
| title_short | Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver Nanoparticles |
| title_sort | recent advances in the delivery mechanism of action and antibacterial activity of silver nanoparticles |
| topic | anti-microbial resistance delivery mechanism of action silver nanoparticles |
| url | https://ujmr.umyu.edu.ng/index.php/ujmr/article/view/558 |
| work_keys_str_mv | AT idrisnu recentadvancesinthedeliverymechanismofactionandantibacterialactivityofsilvernanoparticles AT farukfu recentadvancesinthedeliverymechanismofactionandantibacterialactivityofsilvernanoparticles AT yerimami recentadvancesinthedeliverymechanismofactionandantibacterialactivityofsilvernanoparticles AT isaak recentadvancesinthedeliverymechanismofactionandantibacterialactivityofsilvernanoparticles |