Diagnostic value of AATs to β1- AR in elderly patients with chronic heart failure
Aim. To study the deterioration of myocardial contractility in ischemic heart diseases. Methods and results. We have examined 98 patients aged 69.5±7.9 years, including 65 people with coronary heart disease: stable tension angina EFII-III,CH IIA-IIB degree and 33patients without heart failure wit...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2014-10-01
|
| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/28743/25741 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850229634498560000 |
|---|---|
| author | V. Yu. Zharynova V. A. Tabakovych-Vatseba |
| author_facet | V. Yu. Zharynova V. A. Tabakovych-Vatseba |
| author_sort | V. Yu. Zharynova |
| collection | DOAJ |
| description | Aim. To study the deterioration of myocardial contractility in ischemic heart diseases.
Methods and results. We have examined 98 patients aged 69.5±7.9 years, including 65 people with coronary heart disease: stable tension angina EFII-III,CH IIA-IIB degree and 33patients without heart failure with preserved left ventricular ejection fraction (EF> 45%). At the initial stage all patients underwent VLP registration, echocardiography, and also testing the level of cardiotropic AABs using ELISA immunoassay. The levels of AABs to β1-AR, Com-02, Cos-05, L-myosin. Thus, in the group with elevated systolic myocardial dysfunction a high AAB titer to β1-AR was detected in 68.5% of patients, while in the group with normal left ventricular ejection fraction, only in 34.2%.
Conclusions. Thus, the obtained data suggest that the deterioration of myocardial contractility in ischemic heart diseases is associated with an increased titer of β1-AR. |
| format | Article |
| id | doaj-art-2a97a36caf024c898a5e81c433d8f73c |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-2a97a36caf024c898a5e81c433d8f73c2025-08-20T02:04:09ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102014-10-0151823http://dx.doi.org/10.14739/2310-1210.2014.5.28743Diagnostic value of AATs to β1- AR in elderly patients with chronic heart failureV. Yu. Zharynova V. A. Tabakovych-VatsebaAim. To study the deterioration of myocardial contractility in ischemic heart diseases. Methods and results. We have examined 98 patients aged 69.5±7.9 years, including 65 people with coronary heart disease: stable tension angina EFII-III,CH IIA-IIB degree and 33patients without heart failure with preserved left ventricular ejection fraction (EF> 45%). At the initial stage all patients underwent VLP registration, echocardiography, and also testing the level of cardiotropic AABs using ELISA immunoassay. The levels of AABs to β1-AR, Com-02, Cos-05, L-myosin. Thus, in the group with elevated systolic myocardial dysfunction a high AAB titer to β1-AR was detected in 68.5% of patients, while in the group with normal left ventricular ejection fraction, only in 34.2%. Conclusions. Thus, the obtained data suggest that the deterioration of myocardial contractility in ischemic heart diseases is associated with an increased titer of β1-AR.http://zmj.zsmu.edu.ua/article/view/28743/25741AutoantibodiesChronic Heart FailureAdrenergic ReceptorChronic Heart Disease |
| spellingShingle | V. Yu. Zharynova V. A. Tabakovych-Vatseba Diagnostic value of AATs to β1- AR in elderly patients with chronic heart failure Zaporožskij Medicinskij Žurnal Autoantibodies Chronic Heart Failure Adrenergic Receptor Chronic Heart Disease |
| title | Diagnostic value of AATs to β1- AR in elderly patients with chronic heart failure |
| title_full | Diagnostic value of AATs to β1- AR in elderly patients with chronic heart failure |
| title_fullStr | Diagnostic value of AATs to β1- AR in elderly patients with chronic heart failure |
| title_full_unstemmed | Diagnostic value of AATs to β1- AR in elderly patients with chronic heart failure |
| title_short | Diagnostic value of AATs to β1- AR in elderly patients with chronic heart failure |
| title_sort | diagnostic value of aats to β1 ar in elderly patients with chronic heart failure |
| topic | Autoantibodies Chronic Heart Failure Adrenergic Receptor Chronic Heart Disease |
| url | http://zmj.zsmu.edu.ua/article/view/28743/25741 |
| work_keys_str_mv | AT vyuzharynova diagnosticvalueofaatstob1arinelderlypatientswithchronicheartfailure AT vatabakovychvatseba diagnosticvalueofaatstob1arinelderlypatientswithchronicheartfailure |