In vivo imaging of the spatial heterogeneity of intratumoral acidosis (pH) as a marker of the metastatic phenotype in breast cancer

In vivo imaging of the spatial heterogeneity of intratumoral acidosis (pH) as a marker of the metastatic phenotype in breast cancer

Abstract Background Metabolic alterations, including acidosis in the tumor microenvironment, have been extensively linked to more aggressive phenotypes and increased therapy resistance. However, current imaging techniques are limited in their ability to capture extracellular tumor acidosis precisely...

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Main Authors: Alessia Corrado, Nicla Lorito, Annasofia Anemone, Antonella Carella, Daisy Villano, Elisa Pirotta, Francesco Gammaraccio, Angela Subbiani, Marina Bacci, Walter Dastrù, Andrea Morandi, Dario Livio Longo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Breast Cancer Research
Subjects:
Tumor metabolism
Tumor acidosis
Breast cancer
Imaging
MRI
Chemical exchange saturation transfer (CEST)
Online Access:https://doi.org/10.1186/s13058-025-02065-y
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