MYC promotes group 3 medulloblastoma cell proliferation and alleviates ROS-induced cell death by upregulating transketolase

MYC promotes group 3 medulloblastoma cell proliferation and alleviates ROS-induced cell death by upregulating transketolase

Abstract Medulloblastoma is a common embryonic malignant tumor in children. Patients with Group 3 medulloblastoma exhibit the poorest prognosis among all subgroups, and approximately 20% of these patients carry an amplification of MYC. Metabolic reprogramming, a hallmark of cancer, includes the pent...

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Bibliographic Details
Main Authors: Shizun Wang, Dan Zhang, Chunlong Wang, Yuqin Liu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Acta Neuropathologica Communications
Subjects:
Group 3 medulloblastoma
MYC
TKT
Cell proliferation
ROS-induced injury
Online Access:https://doi.org/10.1186/s40478-025-02051-7
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