Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping review
Abstract Background Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. PD is diagnosed by a combination of motor symptoms including bradykinesia, resting tremors, rigidity and postural instabil...
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BMC
2025-03-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-025-01620-5 |
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| author | Ibrahim Serag Ahmed Y. Azzam Amr K. Hassan Rehab Adel Diab Mohamed Diab Mahmoud Tarek Hefnawy Mohamed Ahmed Ali Ahmed Negida |
| author_facet | Ibrahim Serag Ahmed Y. Azzam Amr K. Hassan Rehab Adel Diab Mohamed Diab Mahmoud Tarek Hefnawy Mohamed Ahmed Ali Ahmed Negida |
| author_sort | Ibrahim Serag |
| collection | DOAJ |
| description | Abstract Background Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. PD is diagnosed by a combination of motor symptoms including bradykinesia, resting tremors, rigidity and postural instability. Prodromal PD is the stage preceding the onset of classic motor symptoms of PD. The diagnosis of prodromal PD remains challenging despite many available diagnostic modalities. Aim This scoping review aims to investigate and explore the current diagnostic modalities used to detect prodromal PD, focusing particularly on multimodal imaging analysis and AI-based approaches. Methods We adhered to the PRISMA-SR guidelines for scoping reviews. We conducted a comprehensive literature search at multiple databases such as PubMed, Scopus, Web of Science, and the Cochrane Library from inception to July 2024, using keywords related to prodromal PD and diagnostic modalities. We included studies based on predefined inclusion and exclusion criteria and performed data extraction using a standardized form. Results The search included 9 studies involving 567 patients with prodromal PD and 35,643 control. Studies utilized various diagnostic approaches including neuroimaging techniques and AI-driven models. sensitivity ranging from 43 to 84% and specificity up to 96%. Neuroimaging and AI technologies showed promising results in identifying early pathological changes and predicting PD onset. The highest specificity was achieved by neuromelanin-sensitive imaging model, while highest sensitivity was achieved by standard 10-s electrocardiogram (ECG) + Machine learning model. Conclusion Advanced diagnostic modalities such as AI-driven models and multimodal neuroimaging revealed promising results in early detection of prodromal PD. However, their clinical application as screening tool for prodromal PD is limited because of the lack of validation. Future research should be directed towards using Multimodal imaging in diagnosing and screening for prodromal PD. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-2a8f8c6e0cbd4d2e9ce54f9a58f3b89a |
| institution | OA Journals |
| issn | 1471-2342 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj-art-2a8f8c6e0cbd4d2e9ce54f9a58f3b89a2025-08-20T02:10:17ZengBMCBMC Medical Imaging1471-23422025-03-0125111210.1186/s12880-025-01620-5Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping reviewIbrahim Serag0Ahmed Y. Azzam1Amr K. Hassan2Rehab Adel Diab3Mohamed Diab4Mahmoud Tarek Hefnawy5Mohamed Ahmed Ali6Ahmed Negida7Faculty of Medicine, Mansoura UniversityFaculty of Medicine, October 6 UniversityMedical Research Group of Egypt, Negida AcademyFaculty of medicine, Al-Azhar universityFaculty of Medicine, Alexandria UniversityFaculty of Medicine, Zagazig UniversityQena Faculty of Medicine, South Valley UniversityMedical Research Group of Egypt, Negida AcademyAbstract Background Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. PD is diagnosed by a combination of motor symptoms including bradykinesia, resting tremors, rigidity and postural instability. Prodromal PD is the stage preceding the onset of classic motor symptoms of PD. The diagnosis of prodromal PD remains challenging despite many available diagnostic modalities. Aim This scoping review aims to investigate and explore the current diagnostic modalities used to detect prodromal PD, focusing particularly on multimodal imaging analysis and AI-based approaches. Methods We adhered to the PRISMA-SR guidelines for scoping reviews. We conducted a comprehensive literature search at multiple databases such as PubMed, Scopus, Web of Science, and the Cochrane Library from inception to July 2024, using keywords related to prodromal PD and diagnostic modalities. We included studies based on predefined inclusion and exclusion criteria and performed data extraction using a standardized form. Results The search included 9 studies involving 567 patients with prodromal PD and 35,643 control. Studies utilized various diagnostic approaches including neuroimaging techniques and AI-driven models. sensitivity ranging from 43 to 84% and specificity up to 96%. Neuroimaging and AI technologies showed promising results in identifying early pathological changes and predicting PD onset. The highest specificity was achieved by neuromelanin-sensitive imaging model, while highest sensitivity was achieved by standard 10-s electrocardiogram (ECG) + Machine learning model. Conclusion Advanced diagnostic modalities such as AI-driven models and multimodal neuroimaging revealed promising results in early detection of prodromal PD. However, their clinical application as screening tool for prodromal PD is limited because of the lack of validation. Future research should be directed towards using Multimodal imaging in diagnosing and screening for prodromal PD. Clinical trial number Not applicable.https://doi.org/10.1186/s12880-025-01620-5MRIECGAIMultimodal diagnostic imagingProdromal PDScoping review |
| spellingShingle | Ibrahim Serag Ahmed Y. Azzam Amr K. Hassan Rehab Adel Diab Mohamed Diab Mahmoud Tarek Hefnawy Mohamed Ahmed Ali Ahmed Negida Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping review BMC Medical Imaging MRI ECG AI Multimodal diagnostic imaging Prodromal PD Scoping review |
| title | Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping review |
| title_full | Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping review |
| title_fullStr | Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping review |
| title_full_unstemmed | Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping review |
| title_short | Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping review |
| title_sort | multimodal diagnostic tools and advanced data models for detection of prodromal parkinson s disease a scoping review |
| topic | MRI ECG AI Multimodal diagnostic imaging Prodromal PD Scoping review |
| url | https://doi.org/10.1186/s12880-025-01620-5 |
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