Oxygenation of the Intraportally Transplanted Pancreatic Islet
Intraportal islet transplantation (IT) is not widely utilized as a treatment for type 1 diabetes. Oxygenation of the intraportally transplanted islet has not been studied extensively. We present a diffusion-reaction model that predicts the presence of an anoxic core and a larger partly functional co...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/7625947 |
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| author | Thomas M. Suszynski Efstathios S. Avgoustiniatos Klearchos K. Papas |
| author_facet | Thomas M. Suszynski Efstathios S. Avgoustiniatos Klearchos K. Papas |
| author_sort | Thomas M. Suszynski |
| collection | DOAJ |
| description | Intraportal islet transplantation (IT) is not widely utilized as a treatment for type 1 diabetes. Oxygenation of the intraportally transplanted islet has not been studied extensively. We present a diffusion-reaction model that predicts the presence of an anoxic core and a larger partly functional core within intraportally transplanted islets. Four variables were studied: islet diameter, islet fractional viability, external oxygen partial pressure (P) (in surrounding portal blood), and presence or absence of a thrombus on the islet surface. Results indicate that an islet with average size and fractional viability exhibits an anoxic volume fraction (AVF) of 14% and a function loss of 72% at a low external P. Thrombus formation increased AVF to 30% and function loss to 92%, suggesting that the effect of thrombosis may be substantial. External P and islet diameter accounted for the greatest overall impact on AVF and loss of function. At our institutions, large human alloislets (>200 μm diameter) account for ~20% of total islet number but ~70% of total islet volume; since most of the total transplanted islet volume is accounted for by large islets, most of the intraportal islet cells are likely to be anoxic and not fully functional. |
| format | Article |
| id | doaj-art-2a8e54a51b294e139a6afef704bc3f29 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2a8e54a51b294e139a6afef704bc3f292025-02-03T06:44:31ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/76259477625947Oxygenation of the Intraportally Transplanted Pancreatic IsletThomas M. Suszynski0Efstathios S. Avgoustiniatos1Klearchos K. Papas2Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USADepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USADepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USAIntraportal islet transplantation (IT) is not widely utilized as a treatment for type 1 diabetes. Oxygenation of the intraportally transplanted islet has not been studied extensively. We present a diffusion-reaction model that predicts the presence of an anoxic core and a larger partly functional core within intraportally transplanted islets. Four variables were studied: islet diameter, islet fractional viability, external oxygen partial pressure (P) (in surrounding portal blood), and presence or absence of a thrombus on the islet surface. Results indicate that an islet with average size and fractional viability exhibits an anoxic volume fraction (AVF) of 14% and a function loss of 72% at a low external P. Thrombus formation increased AVF to 30% and function loss to 92%, suggesting that the effect of thrombosis may be substantial. External P and islet diameter accounted for the greatest overall impact on AVF and loss of function. At our institutions, large human alloislets (>200 μm diameter) account for ~20% of total islet number but ~70% of total islet volume; since most of the total transplanted islet volume is accounted for by large islets, most of the intraportal islet cells are likely to be anoxic and not fully functional.http://dx.doi.org/10.1155/2016/7625947 |
| spellingShingle | Thomas M. Suszynski Efstathios S. Avgoustiniatos Klearchos K. Papas Oxygenation of the Intraportally Transplanted Pancreatic Islet Journal of Diabetes Research |
| title | Oxygenation of the Intraportally Transplanted Pancreatic Islet |
| title_full | Oxygenation of the Intraportally Transplanted Pancreatic Islet |
| title_fullStr | Oxygenation of the Intraportally Transplanted Pancreatic Islet |
| title_full_unstemmed | Oxygenation of the Intraportally Transplanted Pancreatic Islet |
| title_short | Oxygenation of the Intraportally Transplanted Pancreatic Islet |
| title_sort | oxygenation of the intraportally transplanted pancreatic islet |
| url | http://dx.doi.org/10.1155/2016/7625947 |
| work_keys_str_mv | AT thomasmsuszynski oxygenationoftheintraportallytransplantedpancreaticislet AT efstathiossavgoustiniatos oxygenationoftheintraportallytransplantedpancreaticislet AT klearchoskpapas oxygenationoftheintraportallytransplantedpancreaticislet |