The interplay of iron, oxidative stress, and α-synuclein in Parkinson’s disease progression

The interplay of iron, oxidative stress, and α-synuclein in Parkinson’s disease progression

Abstract The irreversible degeneration of dopamine neurons induced by α-synuclein (α-syn) aggregation in the substantia nigra is the central pathological feature of Parkinson's disease (PD). Neuroimaging and pathological autopsy studies consistently confirm significant iron accumulation in the...

Full description

Saved in:
Bibliographic Details
Main Authors: Yan Chen, Xixi Luo, Yukun Yin, Elizabeth Rosalind Thomas, Kezhi Liu, Wenjun Wang, Xiang Li
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Medicine
Subjects:
Parkinson's disease
α-synuclein
Ferroptosis
Iron
Online Access:https://doi.org/10.1186/s10020-025-01208-3
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items