Maternal Plasma Elabela, a Biomarker for the Severity and Kidney Function of Human Preeclampsia
Background: It reported that serum Elabela level was decreased in preeclampsia patients. However, there is no researcher done the study on the correlations between plasma Elabela and kidney function, blood pressure, blood glucose and lipid in preeclampsia patients. Our objective is determined whethe...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-09-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/49/10/10.31083/j.ceog4910214 |
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| author | Miaoyan Ma Yuemin Hou Jinfang Wu Yanhua Qi |
| author_facet | Miaoyan Ma Yuemin Hou Jinfang Wu Yanhua Qi |
| author_sort | Miaoyan Ma |
| collection | DOAJ |
| description | Background: It reported that serum Elabela level was decreased in preeclampsia patients. However, there is no researcher done the study on the correlations between plasma Elabela and kidney function, blood pressure, blood glucose and lipid in preeclampsia patients. Our objective is determined whether plasma Elabela could be a marker for the severity and kidney function of preeclampsia. Methods: 72 pregnant women were enrolled in this study and divided into healthy group (n = 37), mild preeclampsia group (n = 20) and severe preeclampsia group (n = 15). The level of plasma Elabela was detected using ELISA. Results: Plasma Elabela was reduced in preeclampsia patients compared to healthy group, and severe preeclampsia patients had the lower level of Elabela and poorer kidney function. The level of plasma Elabela was negatively correlated with those of uric acid (UA), creatinine (Cre), cystatin C (CysC), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Conclusions: Lower concentration of plasma Elabela correlated with worse kidney function, and higher blood pressures in preeclampsia patients. |
| format | Article |
| id | doaj-art-2a8c9e9f8d8d47c2bdf43188cfd3a62c |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-2a8c9e9f8d8d47c2bdf43188cfd3a62c2025-08-20T02:01:42ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-09-01491021410.31083/j.ceog4910214S0390-6663(22)01820-6Maternal Plasma Elabela, a Biomarker for the Severity and Kidney Function of Human PreeclampsiaMiaoyan Ma0Yuemin Hou1Jinfang Wu2Yanhua Qi3Department of Ultrasound, the Second Affiliated Hospital, Xi'an Jiaotong University, 710004 Xi'an, Shaanxi, ChinaDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital, Xi'an Jiaotong University, 710004 Xi'an, Shaanxi, ChinaDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital, Xi'an Jiaotong University, 710004 Xi'an, Shaanxi, ChinaDepartment of Ultrasound, the Second Affiliated Hospital, Xi'an Jiaotong University, 710004 Xi'an, Shaanxi, ChinaBackground: It reported that serum Elabela level was decreased in preeclampsia patients. However, there is no researcher done the study on the correlations between plasma Elabela and kidney function, blood pressure, blood glucose and lipid in preeclampsia patients. Our objective is determined whether plasma Elabela could be a marker for the severity and kidney function of preeclampsia. Methods: 72 pregnant women were enrolled in this study and divided into healthy group (n = 37), mild preeclampsia group (n = 20) and severe preeclampsia group (n = 15). The level of plasma Elabela was detected using ELISA. Results: Plasma Elabela was reduced in preeclampsia patients compared to healthy group, and severe preeclampsia patients had the lower level of Elabela and poorer kidney function. The level of plasma Elabela was negatively correlated with those of uric acid (UA), creatinine (Cre), cystatin C (CysC), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Conclusions: Lower concentration of plasma Elabela correlated with worse kidney function, and higher blood pressures in preeclampsia patients.https://www.imrpress.com/journal/CEOG/49/10/10.31083/j.ceog4910214biomarkerblood pressureelabelakidney functionpreeclampsia |
| spellingShingle | Miaoyan Ma Yuemin Hou Jinfang Wu Yanhua Qi Maternal Plasma Elabela, a Biomarker for the Severity and Kidney Function of Human Preeclampsia Clinical and Experimental Obstetrics & Gynecology biomarker blood pressure elabela kidney function preeclampsia |
| title | Maternal Plasma Elabela, a Biomarker for the Severity and Kidney Function of Human Preeclampsia |
| title_full | Maternal Plasma Elabela, a Biomarker for the Severity and Kidney Function of Human Preeclampsia |
| title_fullStr | Maternal Plasma Elabela, a Biomarker for the Severity and Kidney Function of Human Preeclampsia |
| title_full_unstemmed | Maternal Plasma Elabela, a Biomarker for the Severity and Kidney Function of Human Preeclampsia |
| title_short | Maternal Plasma Elabela, a Biomarker for the Severity and Kidney Function of Human Preeclampsia |
| title_sort | maternal plasma elabela a biomarker for the severity and kidney function of human preeclampsia |
| topic | biomarker blood pressure elabela kidney function preeclampsia |
| url | https://www.imrpress.com/journal/CEOG/49/10/10.31083/j.ceog4910214 |
| work_keys_str_mv | AT miaoyanma maternalplasmaelabelaabiomarkerfortheseverityandkidneyfunctionofhumanpreeclampsia AT yueminhou maternalplasmaelabelaabiomarkerfortheseverityandkidneyfunctionofhumanpreeclampsia AT jinfangwu maternalplasmaelabelaabiomarkerfortheseverityandkidneyfunctionofhumanpreeclampsia AT yanhuaqi maternalplasmaelabelaabiomarkerfortheseverityandkidneyfunctionofhumanpreeclampsia |