Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheep
With the increase of cadmium content in the environment, the losses caused by cadmium-induced intestinal diseases to animal husbandry are increasing year by year. However, most of the on-going research activities focus on zoonotic diseases rather than exploring the mechanisms of animal disease occur...
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Elsevier
2024-10-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324010807 |
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| author | Huimin Zhang Shuo Yan Ruilin Du Yue Xue Wenna Yao Teligun Yulong Zhao Yongfa Li Hanggai Bao Shuo Cao Xihe Li Siqin Bao Yongli Song |
| author_facet | Huimin Zhang Shuo Yan Ruilin Du Yue Xue Wenna Yao Teligun Yulong Zhao Yongfa Li Hanggai Bao Shuo Cao Xihe Li Siqin Bao Yongli Song |
| author_sort | Huimin Zhang |
| collection | DOAJ |
| description | With the increase of cadmium content in the environment, the losses caused by cadmium-induced intestinal diseases to animal husbandry are increasing year by year. However, most of the on-going research activities focus on zoonotic diseases rather than exploring the mechanisms of animal disease occurrence from an anthropogenic environmental perspective. In this study, stressed Hu sheep under cadmium environmental exposure were selected to explore the mechanism of inflammatory bowel disease development. 16 s, untargeted metabolomics and transcriptomic multiomics were used to analyze the changes of their intestinal tract and intestinal contents. The results showed that the beneficial microorganisms (s_Ruminococcus_sp) in the Cd group were significantly decreased and the potentially harmful microorganisms were significantly enriched, and the changes of these microorganisms affected the changes of metabolites (caprylic acid) to a certain extent, resulting in a decrease in fatty acids in the intestine. Due to the combined effect of cadmium ion and fatty acid reduction, the PPAR signaling pathway was inhibited, and the fatty acid transport and binding were further reduced, causing very serious damage to the intestine. We revealed for the first time the mechanism of intestinal injury in Hu sheeps under cadmium environmental exposure and provided new prevention and treatment methods of intestinal diseases under the environmental exposure to trace metals. |
| format | Article |
| id | doaj-art-2a8c7a569c91445d9f18f56e66672e36 |
| institution | OA Journals |
| issn | 0147-6513 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-2a8c7a569c91445d9f18f56e66672e362025-08-20T01:54:44ZengElsevierEcotoxicology and Environmental Safety0147-65132024-10-0128411700410.1016/j.ecoenv.2024.117004Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheepHuimin Zhang0Shuo Yan1Ruilin Du2Yue Xue3Wenna Yao4 Teligun5Yulong Zhao6Yongfa Li7Hanggai Bao8Shuo Cao9Xihe Li10Siqin Bao11Yongli Song12Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, ChinaResearch Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot 011517, China; Correspondence to: Bao Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Xilinguole, Rd.49.Yuquan District, Hohhot 010020, China.Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; Correspondence to: Bao Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Xilinguole, Rd.49.Yuquan District, Hohhot 010020, China.Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010020, China; Correspondence to: Bao Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Xilinguole, Rd.49.Yuquan District, Hohhot 010020, China.With the increase of cadmium content in the environment, the losses caused by cadmium-induced intestinal diseases to animal husbandry are increasing year by year. However, most of the on-going research activities focus on zoonotic diseases rather than exploring the mechanisms of animal disease occurrence from an anthropogenic environmental perspective. In this study, stressed Hu sheep under cadmium environmental exposure were selected to explore the mechanism of inflammatory bowel disease development. 16 s, untargeted metabolomics and transcriptomic multiomics were used to analyze the changes of their intestinal tract and intestinal contents. The results showed that the beneficial microorganisms (s_Ruminococcus_sp) in the Cd group were significantly decreased and the potentially harmful microorganisms were significantly enriched, and the changes of these microorganisms affected the changes of metabolites (caprylic acid) to a certain extent, resulting in a decrease in fatty acids in the intestine. Due to the combined effect of cadmium ion and fatty acid reduction, the PPAR signaling pathway was inhibited, and the fatty acid transport and binding were further reduced, causing very serious damage to the intestine. We revealed for the first time the mechanism of intestinal injury in Hu sheeps under cadmium environmental exposure and provided new prevention and treatment methods of intestinal diseases under the environmental exposure to trace metals.http://www.sciencedirect.com/science/article/pii/S0147651324010807MicrobialMetabolitesCaprylic acidFatty acid metabolismPPAR signaling pathway |
| spellingShingle | Huimin Zhang Shuo Yan Ruilin Du Yue Xue Wenna Yao Teligun Yulong Zhao Yongfa Li Hanggai Bao Shuo Cao Xihe Li Siqin Bao Yongli Song Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheep Ecotoxicology and Environmental Safety Microbial Metabolites Caprylic acid Fatty acid metabolism PPAR signaling pathway |
| title | Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheep |
| title_full | Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheep |
| title_fullStr | Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheep |
| title_full_unstemmed | Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheep |
| title_short | Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheep |
| title_sort | cadmium exposure promotes inflammation through the ppar signaling pathway in the small intestine and colon of hu sheep |
| topic | Microbial Metabolites Caprylic acid Fatty acid metabolism PPAR signaling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324010807 |
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