The Pathogenesis and Treatment of Insomnia Combined with Depression
Yifan Chang,1 Lu Liu,1 Xiaodong Xu,2 Shiqiang Zhang2 1Acupuncture and Moxibustion Department, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Hebei Province Key Laboratory of Integrated Traditional and Western Medicine in Neurological Rehabilitation, Hebei Province...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2025-08-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/the-pathogenesis-and-treatment-of-insomnia-combined-with-depression-peer-reviewed-fulltext-article-IJGM |
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| author | Chang Y Liu L Xu X Zhang S |
| author_facet | Chang Y Liu L Xu X Zhang S |
| author_sort | Chang Y |
| collection | DOAJ |
| description | Yifan Chang,1 Lu Liu,1 Xiaodong Xu,2 Shiqiang Zhang2 1Acupuncture and Moxibustion Department, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Hebei Province Key Laboratory of Integrated Traditional and Western Medicine in Neurological Rehabilitation, Hebei Province Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, People’s Republic of ChinaCorrespondence: Shiqiang Zhang, Hebei Province Key Laboratory of Integrated Traditional and Western Medicine in Neurological Rehabilitation, Hebei Province Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, People’s Republic of China, Email zhangshiqiang0811@163.comAbstract: Under the fast pace and high pressure of modern society, many people suffer from sleep disorders such as insomnia, and then suffer from depression and anxiety. This article may lead to a better understanding of the mechanisms of insomnia combined with depression and its treatment. Vital and meaningful, these mechanisms include synaptic plasticity, neurotransmitter dysfunction, the hypothalamic-pituitary-adrenocortical (HPA) axis, and diminished brain-derived neurotrophic factor (BDNF) levels. Evidence for mechanism-guided integrated therapies is scarce. In clinical practice, pharmacological therapies, including antidepressants, Cognitive behavioural therapy(CBT), physiotherapeutics, acupuncture treatment, and mindfulness interventions, are generally utilised. A more profound comprehension of the pathophysiological mechanisms and the development of comprehensive and effective treatment strategies for insomnia co-occurring with depression can enhance neuropsychiatrists’ ability to manage this comorbidity more effectively. This study bridges these gaps by delineating novel neurobiological crosslinks underlying comorbidity and establishing a targeted combined intervention protocol.Keywords: insomnia, sleep, pathogenesis, cognitive behavioral therapy, depression |
| format | Article |
| id | doaj-art-2a8142bda0f944f99530229c2a11c096 |
| institution | Kabale University |
| issn | 1178-7074 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj-art-2a8142bda0f944f99530229c2a11c0962025-08-24T17:31:58ZengDove Medical PressInternational Journal of General Medicine1178-70742025-08-01Volume 18Issue 146354645106083The Pathogenesis and Treatment of Insomnia Combined with DepressionChang Y0Liu LXu X1Zhang SRehabilitationRehabilitation departmentYifan Chang,1 Lu Liu,1 Xiaodong Xu,2 Shiqiang Zhang2 1Acupuncture and Moxibustion Department, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Hebei Province Key Laboratory of Integrated Traditional and Western Medicine in Neurological Rehabilitation, Hebei Province Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, People’s Republic of ChinaCorrespondence: Shiqiang Zhang, Hebei Province Key Laboratory of Integrated Traditional and Western Medicine in Neurological Rehabilitation, Hebei Province Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, People’s Republic of China, Email zhangshiqiang0811@163.comAbstract: Under the fast pace and high pressure of modern society, many people suffer from sleep disorders such as insomnia, and then suffer from depression and anxiety. This article may lead to a better understanding of the mechanisms of insomnia combined with depression and its treatment. Vital and meaningful, these mechanisms include synaptic plasticity, neurotransmitter dysfunction, the hypothalamic-pituitary-adrenocortical (HPA) axis, and diminished brain-derived neurotrophic factor (BDNF) levels. Evidence for mechanism-guided integrated therapies is scarce. In clinical practice, pharmacological therapies, including antidepressants, Cognitive behavioural therapy(CBT), physiotherapeutics, acupuncture treatment, and mindfulness interventions, are generally utilised. A more profound comprehension of the pathophysiological mechanisms and the development of comprehensive and effective treatment strategies for insomnia co-occurring with depression can enhance neuropsychiatrists’ ability to manage this comorbidity more effectively. This study bridges these gaps by delineating novel neurobiological crosslinks underlying comorbidity and establishing a targeted combined intervention protocol.Keywords: insomnia, sleep, pathogenesis, cognitive behavioral therapy, depressionhttps://www.dovepress.com/the-pathogenesis-and-treatment-of-insomnia-combined-with-depression-peer-reviewed-fulltext-article-IJGMInsomniasleeppathogenesis；cognitive behavioral therapydepression |
| spellingShingle | Chang Y Liu L Xu X Zhang S The Pathogenesis and Treatment of Insomnia Combined with Depression International Journal of General Medicine Insomnia sleep pathogenesis；cognitive behavioral therapy depression |
| title | The Pathogenesis and Treatment of Insomnia Combined with Depression |
| title_full | The Pathogenesis and Treatment of Insomnia Combined with Depression |
| title_fullStr | The Pathogenesis and Treatment of Insomnia Combined with Depression |
| title_full_unstemmed | The Pathogenesis and Treatment of Insomnia Combined with Depression |
| title_short | The Pathogenesis and Treatment of Insomnia Combined with Depression |
| title_sort | pathogenesis and treatment of insomnia combined with depression |
| topic | Insomnia sleep pathogenesis；cognitive behavioral therapy depression |
| url | https://www.dovepress.com/the-pathogenesis-and-treatment-of-insomnia-combined-with-depression-peer-reviewed-fulltext-article-IJGM |
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