Leukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phase
Introduction. Extramedullary sites of leukemic proliferation, harboring an adverse outcome, are rare and usually found in the blastic phase of chronic myeloid leukemia. We report a case of a newly diagnosed patient with chronic myeloid leukemia in the chronic phase, with leukemic infiltration of the...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2022-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100062S.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849702434013708288 |
|---|---|
| author | Sekulić Borivoj Perčić Ivanka Dragičević-Jojkić Marina Dokić Marina Panjković Milana |
| author_facet | Sekulić Borivoj Perčić Ivanka Dragičević-Jojkić Marina Dokić Marina Panjković Milana |
| author_sort | Sekulić Borivoj |
| collection | DOAJ |
| description | Introduction. Extramedullary sites of leukemic proliferation, harboring an adverse outcome, are rare and usually found in the blastic phase of chronic myeloid leukemia. We report a case of a newly diagnosed patient with chronic myeloid leukemia in the chronic phase, with leukemic infiltration of the right ovary on disease presentation. Case report. The patient presented with abdominal pain, leukocytosis, and anemia. A peripheral blood smear indicated chronic myeloid leukemia, and cytoreductive treatment was started. Due to the worsening of the abdominal pain, computed tomography was done. It revealed a cystic tumor of the right ovary. The tumor was surgically removed. Bone marrow examination confirmed the diagnosis of chronic myeloid leukemia in the chronic phase. Immunohistochemical analysis of the ovarian tumor showed leukemic infiltration with 5% of blasts. The patient was treated with imatinib for one year. Due to treatment failure, imatinib was switched to nilotinib. Allogeneic stem cell transplantation was considered. Conclusion. This case highlights the critical role of the multidisciplinary team approach and close treatment monitoring to achieve the best possible outcome in these patients. |
| format | Article |
| id | doaj-art-2a8134e3e1a445b5ab9a4413dbea3d3f |
| institution | DOAJ |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-2a8134e3e1a445b5ab9a4413dbea3d3f2025-08-20T03:17:39ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202022-01-0179111149115210.2298/VSP210430062S0042-84502100062SLeukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phaseSekulić Borivoj0Perčić Ivanka1https://orcid.org/0000-0002-3462-5338Dragičević-Jojkić Marina2https://orcid.org/0000-0002-7006-9199Dokić Marina3Panjković Milana4University Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + University Clinical Center of Vojvodina, Department of Pathology and Histology, Novi Sad, SerbiaIntroduction. Extramedullary sites of leukemic proliferation, harboring an adverse outcome, are rare and usually found in the blastic phase of chronic myeloid leukemia. We report a case of a newly diagnosed patient with chronic myeloid leukemia in the chronic phase, with leukemic infiltration of the right ovary on disease presentation. Case report. The patient presented with abdominal pain, leukocytosis, and anemia. A peripheral blood smear indicated chronic myeloid leukemia, and cytoreductive treatment was started. Due to the worsening of the abdominal pain, computed tomography was done. It revealed a cystic tumor of the right ovary. The tumor was surgically removed. Bone marrow examination confirmed the diagnosis of chronic myeloid leukemia in the chronic phase. Immunohistochemical analysis of the ovarian tumor showed leukemic infiltration with 5% of blasts. The patient was treated with imatinib for one year. Due to treatment failure, imatinib was switched to nilotinib. Allogeneic stem cell transplantation was considered. Conclusion. This case highlights the critical role of the multidisciplinary team approach and close treatment monitoring to achieve the best possible outcome in these patients.http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100062S.pdfdrug therapyleukemia, myelogenous, chronic, bcr-abl positiveneoplasm invasivenessovary |
| spellingShingle | Sekulić Borivoj Perčić Ivanka Dragičević-Jojkić Marina Dokić Marina Panjković Milana Leukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phase Vojnosanitetski Pregled drug therapy leukemia, myelogenous, chronic, bcr-abl positive neoplasm invasiveness ovary |
| title | Leukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phase |
| title_full | Leukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phase |
| title_fullStr | Leukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phase |
| title_full_unstemmed | Leukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phase |
| title_short | Leukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phase |
| title_sort | leukemic infiltration of the ovary as an initial presentation of chronic myeloid leukemia in chronic phase |
| topic | drug therapy leukemia, myelogenous, chronic, bcr-abl positive neoplasm invasiveness ovary |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100062S.pdf |
| work_keys_str_mv | AT sekulicborivoj leukemicinfiltrationoftheovaryasaninitialpresentationofchronicmyeloidleukemiainchronicphase AT percicivanka leukemicinfiltrationoftheovaryasaninitialpresentationofchronicmyeloidleukemiainchronicphase AT dragicevicjojkicmarina leukemicinfiltrationoftheovaryasaninitialpresentationofchronicmyeloidleukemiainchronicphase AT dokicmarina leukemicinfiltrationoftheovaryasaninitialpresentationofchronicmyeloidleukemiainchronicphase AT panjkovicmilana leukemicinfiltrationoftheovaryasaninitialpresentationofchronicmyeloidleukemiainchronicphase |