Inhalable ciprofloxacin/polymyxin B dry powders in respiratory infection therapy
The current study focused on the formulation, physicochemical characterization, and antibacterial susceptibility testing of inhalable spray dried powders containing ciprofloxacin (CIP) and polymyxin B sulfate (PMB). CIP nanosuspensions with an average particle diameter of 435.9 ± 9.3 nm were initial...
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| Format: | Article |
| Language: | English |
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Compuscript Ltd
2023-03-01
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| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0050 |
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| author | Zhengqi Xu Hriday Bera Hengzhuang Wang Junwei Wang Dongmei Cun Yu Feng Mingshi Yang |
| author_facet | Zhengqi Xu Hriday Bera Hengzhuang Wang Junwei Wang Dongmei Cun Yu Feng Mingshi Yang |
| author_sort | Zhengqi Xu |
| collection | DOAJ |
| description | The current study focused on the formulation, physicochemical characterization, and antibacterial susceptibility testing of inhalable spray dried powders containing ciprofloxacin (CIP) and polymyxin B sulfate (PMB). CIP nanosuspensions with an average particle diameter of 435.9 ± 9.3 nm were initially obtained using the wet-milling protocol and subsequently co-spray dried with PMB solutions to yield inhalable dry powders. The Powder X-Ray Diffraction (P-XRD) results showed that the wet-milled CIP nanoparticles were in a 4.8 hydrate state, which were transformed to 3.7 hydrates and amorphous materials after co-spray drying. The PMB remained in an amorphous state in the dry powders. Differential Scanning Calorimetry (DSC) analyses revealed that the glass transition temperatures (T g s) of the co–spray dried formulations were higher than the T g of CIP, but lower than the T g of PMB. Fourier Transform Infrared Spectrometer (FTIR) studies suggested the existence of π - π interactions between CIP and PMB in the co-spray dried powders. These powders also retained antimicrobial effects against Pseudomonas aeruginosa strain PAO1. In addition, the spray-dried powder formulations exhibited satisfactory solid-state stability and aerodynamic characteristics when stored under 3% relative humidity and 20 ± 5 °C for 4 months. Overall, the newly developed inhalable CIP/PMB dry powders are a promising therapeutic strategy for respiratory tract infections. |
| format | Article |
| id | doaj-art-2a80f44489d944d680721d9f8b68baed |
| institution | OA Journals |
| issn | 2737-7946 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Compuscript Ltd |
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| series | Acta Materia Medica |
| spelling | doaj-art-2a80f44489d944d680721d9f8b68baed2025-08-20T02:34:56ZengCompuscript LtdActa Materia Medica2737-79462023-03-012214215610.15212/AMM-2022-0050Inhalable ciprofloxacin/polymyxin B dry powders in respiratory infection therapyZhengqi XuHriday BeraHengzhuang WangJunwei WangDongmei CunYu FengMingshi YangThe current study focused on the formulation, physicochemical characterization, and antibacterial susceptibility testing of inhalable spray dried powders containing ciprofloxacin (CIP) and polymyxin B sulfate (PMB). CIP nanosuspensions with an average particle diameter of 435.9 ± 9.3 nm were initially obtained using the wet-milling protocol and subsequently co-spray dried with PMB solutions to yield inhalable dry powders. The Powder X-Ray Diffraction (P-XRD) results showed that the wet-milled CIP nanoparticles were in a 4.8 hydrate state, which were transformed to 3.7 hydrates and amorphous materials after co-spray drying. The PMB remained in an amorphous state in the dry powders. Differential Scanning Calorimetry (DSC) analyses revealed that the glass transition temperatures (T g s) of the co–spray dried formulations were higher than the T g of CIP, but lower than the T g of PMB. Fourier Transform Infrared Spectrometer (FTIR) studies suggested the existence of π - π interactions between CIP and PMB in the co-spray dried powders. These powders also retained antimicrobial effects against Pseudomonas aeruginosa strain PAO1. In addition, the spray-dried powder formulations exhibited satisfactory solid-state stability and aerodynamic characteristics when stored under 3% relative humidity and 20 ± 5 °C for 4 months. Overall, the newly developed inhalable CIP/PMB dry powders are a promising therapeutic strategy for respiratory tract infections.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0050 |
| spellingShingle | Zhengqi Xu Hriday Bera Hengzhuang Wang Junwei Wang Dongmei Cun Yu Feng Mingshi Yang Inhalable ciprofloxacin/polymyxin B dry powders in respiratory infection therapy Acta Materia Medica |
| title | Inhalable ciprofloxacin/polymyxin B dry powders in respiratory infection therapy |
| title_full | Inhalable ciprofloxacin/polymyxin B dry powders in respiratory infection therapy |
| title_fullStr | Inhalable ciprofloxacin/polymyxin B dry powders in respiratory infection therapy |
| title_full_unstemmed | Inhalable ciprofloxacin/polymyxin B dry powders in respiratory infection therapy |
| title_short | Inhalable ciprofloxacin/polymyxin B dry powders in respiratory infection therapy |
| title_sort | inhalable ciprofloxacin polymyxin b dry powders in respiratory infection therapy |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0050 |
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