Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary Perspective
Malignant bowel obstruction (MBO) is a major complication in women with advanced gynecologic cancers which imposes a significant burden on patients, caregivers, and healthcare systems. Symptoms of MBO are challenging to palliate and result in progressive decompensation of already vulnerable patients...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2018/1867238 |
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| author | Yeh Chen Lee Nazlin Jivraj Catherine O’Brien Tanya Chawla Eran Shlomovitz Sarah Buchanan Jenny Lau Jennifer Croke Johane P. Allard Preeti Dhar Stephane Laframboise Sarah E. Ferguson Neesha Dhani Marcus Butler Pamela Ng Terri Stuart-McEwan Pamela Savage Lisa Tinker Amit M. Oza Stephanie Lheureux |
| author_facet | Yeh Chen Lee Nazlin Jivraj Catherine O’Brien Tanya Chawla Eran Shlomovitz Sarah Buchanan Jenny Lau Jennifer Croke Johane P. Allard Preeti Dhar Stephane Laframboise Sarah E. Ferguson Neesha Dhani Marcus Butler Pamela Ng Terri Stuart-McEwan Pamela Savage Lisa Tinker Amit M. Oza Stephanie Lheureux |
| author_sort | Yeh Chen Lee |
| collection | DOAJ |
| description | Malignant bowel obstruction (MBO) is a major complication in women with advanced gynecologic cancers which imposes a significant burden on patients, caregivers, and healthcare systems. Symptoms of MBO are challenging to palliate and result in progressive decompensation of already vulnerable patients with limited therapeutic options and a short prognosis. However, there is a paucity of guidelines or innovative approaches to improve the care of women who develop MBO. MBO is a complex clinical situation that requires a multidisciplinary approach to ensure the appropriate treatment modality and interprofessional care to optimally manage these patients. This review summarizes the current literature on the different approaches targeting MBO management including surgical intervention, chemotherapy, total parenteral nutrition, and pharmacological treatment. In addition, the impact of MBO management on patients’ quality of life (QOL) is examined. This article focuses on the challenges in developing evidence-based treatment guidelines for MBO and barriers in clinical trial design for MBO and proposes strategies to advance the MBO management. Collaboration is essential to design studies that may improve the overall care and quality of life for these patients. Prospective data are needed to inform clinical practice, establish a new benchmark for evidence-based MBO management, and better understand the biology of MBO. |
| format | Article |
| id | doaj-art-2a7d710cabed4002aa6f3212779b983f |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-2a7d710cabed4002aa6f3212779b983f2025-02-03T01:33:10ZengWileyObstetrics and Gynecology International1687-95891687-95972018-01-01201810.1155/2018/18672381867238Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary PerspectiveYeh Chen Lee0Nazlin Jivraj1Catherine O’Brien2Tanya Chawla3Eran Shlomovitz4Sarah Buchanan5Jenny Lau6Jennifer Croke7Johane P. Allard8Preeti Dhar9Stephane Laframboise10Sarah E. Ferguson11Neesha Dhani12Marcus Butler13Pamela Ng14Terri Stuart-McEwan15Pamela Savage16Lisa Tinker17Amit M. Oza18Stephanie Lheureux19Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaPrincess Margaret Cancer Centre, Toronto, ON, CanadaDivision of General Surgery, University Health Network, Toronto, ON, CanadaJoint Department of Medical Imaging, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaDivision of General Surgery, University Health Network, Toronto, ON, CanadaPrincess Margaret Cancer Centre, Toronto, ON, CanadaDivision of Supportive Care, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaRadiation Medicine Program, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaDivision of Gastroenterology, University Health Network, University of Toronto, Toronto, ON, CanadaDivision of General Surgery, University Health Network, Toronto, ON, CanadaDivision of Gynecologic Oncology, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaDivision of Gynecologic Oncology, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaPrincess Margaret Cancer Centre, Toronto, ON, CanadaSolid Tumour Oncology and Gattuso Rapid Diagnostic Centre, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaPrincess Margaret Cancer Centre, Toronto, ON, CanadaAmbulatory Care-Solid Tumour Oncology, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, CanadaMalignant bowel obstruction (MBO) is a major complication in women with advanced gynecologic cancers which imposes a significant burden on patients, caregivers, and healthcare systems. Symptoms of MBO are challenging to palliate and result in progressive decompensation of already vulnerable patients with limited therapeutic options and a short prognosis. However, there is a paucity of guidelines or innovative approaches to improve the care of women who develop MBO. MBO is a complex clinical situation that requires a multidisciplinary approach to ensure the appropriate treatment modality and interprofessional care to optimally manage these patients. This review summarizes the current literature on the different approaches targeting MBO management including surgical intervention, chemotherapy, total parenteral nutrition, and pharmacological treatment. In addition, the impact of MBO management on patients’ quality of life (QOL) is examined. This article focuses on the challenges in developing evidence-based treatment guidelines for MBO and barriers in clinical trial design for MBO and proposes strategies to advance the MBO management. Collaboration is essential to design studies that may improve the overall care and quality of life for these patients. Prospective data are needed to inform clinical practice, establish a new benchmark for evidence-based MBO management, and better understand the biology of MBO.http://dx.doi.org/10.1155/2018/1867238 |
| spellingShingle | Yeh Chen Lee Nazlin Jivraj Catherine O’Brien Tanya Chawla Eran Shlomovitz Sarah Buchanan Jenny Lau Jennifer Croke Johane P. Allard Preeti Dhar Stephane Laframboise Sarah E. Ferguson Neesha Dhani Marcus Butler Pamela Ng Terri Stuart-McEwan Pamela Savage Lisa Tinker Amit M. Oza Stephanie Lheureux Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary Perspective Obstetrics and Gynecology International |
| title | Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary Perspective |
| title_full | Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary Perspective |
| title_fullStr | Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary Perspective |
| title_full_unstemmed | Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary Perspective |
| title_short | Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary Perspective |
| title_sort | malignant bowel obstruction in advanced gynecologic cancers an updated review from a multidisciplinary perspective |
| url | http://dx.doi.org/10.1155/2018/1867238 |
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