CD8+ T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via β-Hydroxybutyrate Suppression in Mouse Colonic Epithelium

CD8+ T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via β-Hydroxybutyrate Suppression in Mouse Colonic Epithelium

Shiyang Huang,1,2,* Lehan Pan,3– 5,* Mingyang Li,1,2 Shu Pang,4– 7 Yue Tian,8 Wen Shi,1,2 Ye Zong,4– 6 Dong Zhang,8– 10 Dan Tian3– 5 1Immunology Research Center for Oral and Systemic Health, Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical Uni...

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Bibliographic Details
Main Authors: Huang S, Pan L, Li M, Pang S, Tian Y, Shi W, Zong Y, Zhang D, Tian D
Format: Article
Language:English
Published: Dove Medical Press 2025-05-01
Series:Journal of Inflammation Research
Subjects:
perforin
CD8+ T cells
inflammatory bowel disease
microbiomes
β-hydroxybutyrate
Online Access:https://www.dovepress.com/cd8-t-cell-derived-perforin-exacerbates-dysbiosis-and-inflammatory-bow-peer-reviewed-fulltext-article-JIR
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