Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status
Aim. To study the structural and functional myocardial characteristics in patients with exertional angina and type 2 diabetes in comparison with those without diabetes to identify combined hemodynamic changes.Material and methods. Patients were divided into two groups depen - ding on the glycemic st...
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«SILICEA-POLIGRAF» LLC
2021-11-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3077 |
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| author | M. A. Kokozheva B. U. Mardanov E. A. Poddubskaya V. A. Kutsenko M. A. Umetov M. N. Mamedov |
| author_facet | M. A. Kokozheva B. U. Mardanov E. A. Poddubskaya V. A. Kutsenko M. A. Umetov M. N. Mamedov |
| author_sort | M. A. Kokozheva |
| collection | DOAJ |
| description | Aim. To study the structural and functional myocardial characteristics in patients with exertional angina and type 2 diabetes in comparison with those without diabetes to identify combined hemodynamic changes.Material and methods. Patients were divided into two groups depen - ding on the glycemic status. The first group consisted of 49 patients (mean age, 57,9±1,04 years; male/female, 35/14) with coronary artery disease (CAD) and type 2 diabetes, while the second one (control) — 51 patients (60,2±0,9 years, 34/17) with CAD and without diabetes. Patients were surveyed using a standard questionnaire that included socio-demographic parameters, behavioral risk factors, clinical status, medications received, and comorbidities. Diagnostic investigations were carried out, including resting electrocardiography, transthoracic echocardiography and cycle ergometry.Results. Among patients with CAD and type 2 diabetes, hypertension occurred 20% more often compared with the control group — 98 vs 78% (p<0,004). According to the electrocardiography, the combination of diabetes and CAD was characterized by various arrhythmias, which were recorded 2,8 times more often than in the group without diabetes. According to echocardiography, signs of left ventricular hypertrophy, systolic and diastolic dysfunction prevailed in people with diabetes. Mean pulmonary artery pressure in patients with diabetes were higher than in patients without carbohydrate metabolism disorders (p<0,004). According to the stress test, exercise tolerance in experimental group patients was lower than in patients in the control group.Conclusion. The combination of chronic CAD and type 2 diabetes is cha - racterized by a more common combination with hypertension, impaired central and intracardiac hemodynamics, as well as left ventricular hypertrophy. In people with diabetes, impaired systolic and diastolic myocardial function is combined with reduced exercise tolerance. |
| format | Article |
| id | doaj-art-2a79716ceef94d0db059fec4b87f774e |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2021-11-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-2a79716ceef94d0db059fec4b87f774e2025-08-20T02:59:14Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252021-11-0120710.15829/1728-8800-2021-30772395Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic statusM. A. Kokozheva0B. U. Mardanov1E. A. Poddubskaya2V. A. Kutsenko3M. A. Umetov4M. N. Mamedov5Sklifosovsky Research Institute for Emergency MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineH.M. Berbekov Kabardino-Balkarian State UniversityNational Medical Research Center for Therapy and Preventive MedicineAim. To study the structural and functional myocardial characteristics in patients with exertional angina and type 2 diabetes in comparison with those without diabetes to identify combined hemodynamic changes.Material and methods. Patients were divided into two groups depen - ding on the glycemic status. The first group consisted of 49 patients (mean age, 57,9±1,04 years; male/female, 35/14) with coronary artery disease (CAD) and type 2 diabetes, while the second one (control) — 51 patients (60,2±0,9 years, 34/17) with CAD and without diabetes. Patients were surveyed using a standard questionnaire that included socio-demographic parameters, behavioral risk factors, clinical status, medications received, and comorbidities. Diagnostic investigations were carried out, including resting electrocardiography, transthoracic echocardiography and cycle ergometry.Results. Among patients with CAD and type 2 diabetes, hypertension occurred 20% more often compared with the control group — 98 vs 78% (p<0,004). According to the electrocardiography, the combination of diabetes and CAD was characterized by various arrhythmias, which were recorded 2,8 times more often than in the group without diabetes. According to echocardiography, signs of left ventricular hypertrophy, systolic and diastolic dysfunction prevailed in people with diabetes. Mean pulmonary artery pressure in patients with diabetes were higher than in patients without carbohydrate metabolism disorders (p<0,004). According to the stress test, exercise tolerance in experimental group patients was lower than in patients in the control group.Conclusion. The combination of chronic CAD and type 2 diabetes is cha - racterized by a more common combination with hypertension, impaired central and intracardiac hemodynamics, as well as left ventricular hypertrophy. In people with diabetes, impaired systolic and diastolic myocardial function is combined with reduced exercise tolerance.https://cardiovascular.elpub.ru/jour/article/view/3077diabetescoronary artery diseasestructural and functional myocardial changesnon-invasive investigationsdiabetescoronary artery diseasestructural and functional myocardial changesnon-invasive investigations |
| spellingShingle | M. A. Kokozheva B. U. Mardanov E. A. Poddubskaya V. A. Kutsenko M. A. Umetov M. N. Mamedov Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status Кардиоваскулярная терапия и профилактика diabetes coronary artery disease structural and functional myocardial changes non-invasive investigationsdiabetes coronary artery disease structural and functional myocardial changes non-invasive investigations |
| title | Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status |
| title_full | Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status |
| title_fullStr | Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status |
| title_full_unstemmed | Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status |
| title_short | Assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status |
| title_sort | assessment of structural and functional myocardial characteristics in patients with chronic coronary artery disease and various glycemic status |
| topic | diabetes coronary artery disease structural and functional myocardial changes non-invasive investigationsdiabetes coronary artery disease structural and functional myocardial changes non-invasive investigations |
| url | https://cardiovascular.elpub.ru/jour/article/view/3077 |
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