Tumor suppressor SLC9A2 inhibits colorectal cancer metastasis and reverses immunotherapy resistance by suppressing angiogenesis

Tumor suppressor SLC9A2 inhibits colorectal cancer metastasis and reverses immunotherapy resistance by suppressing angiogenesis

Abstract Background Colorectal cancer (CRC) is a common and aggressive malignancy that frequently metastasizes to the liver, presenting significant therapeutic challenges. Despite its clinical importance, the mechanisms underlying CRC liver metastasis and resistance to immune therapy remain poorly u...

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Main Authors: Zizhen Zhang, Shengde Liu, Ting Xu, Nan Chen, Cheng Liu, Hong Yang, Yuanmeng Shi, Zhiwei Li, Xujiao Feng, Yanhong Yao, Xiaorui Duan, Gehan Xu, Cheng Zhang, Zhenghang Wang, Jian Li, Lin Shen
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal Cancer
SLC9A2
Angiogenesis
Liver metastasis, immunotherapy
Online Access:https://doi.org/10.1186/s13046-025-03422-7
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