Variation in Ovine <i>KRTAP13-3</i> and Its Association with Wool Characteristics in Chinese Tan Sheep
Understanding the genetic factors that influence wool quality is essential for enhancing wool quality and uniformity. This study investigated the <i>KRTAP13-3</i> gene in Chinese Tan sheep, a breed known for its unique wool characteristics. We analysed 232 sheep and revealed five previou...
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MDPI AG
2025-04-01
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| author | Lingrong Bai Huitong Zhou Jinzhong Tao Jon G. H. Hickford |
| author_facet | Lingrong Bai Huitong Zhou Jinzhong Tao Jon G. H. Hickford |
| author_sort | Lingrong Bai |
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| description | Understanding the genetic factors that influence wool quality is essential for enhancing wool quality and uniformity. This study investigated the <i>KRTAP13-3</i> gene in Chinese Tan sheep, a breed known for its unique wool characteristics. We analysed 232 sheep and revealed five previously identified sequence variants of <i>KRTAP13-3</i> and then modelled to ascertain whether there was any association between the nucleotide sequence variation and variation in mean fibre diameter (MFD), fibre diameter standard deviation (FDSD), coefficient of variation of fibre diameter (CVFD), and mean fibre curvature (MFC). Twelve genotypes were observed, with the five variants having frequencies that ranged from 64.0% to 1.1%. Among the four variants with frequencies above 5%, nucleotide sequence variation was associated with heterotypic hair fibre diameter variation. The most common variant (<i>A</i>) was linked to increased FDSD and CVFD, while two other variants (<i>B</i> and <i>D</i>) revealed trends towards being associated with decreased CVFD. No associations were found with variation in the fine wool fibres from the Tan sheep. This suggests that <i>KRTAP13-3</i> plays a role in regulating heterotypic hair fibre diameter variability and that it could possibly be a gene marker for improving wool traits. |
| format | Article |
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| language | English |
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| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-2a72a8e36a9b46588d389122719e22ad2025-08-20T02:09:14ZengMDPI AGAnimals2076-26152025-04-01157106910.3390/ani15071069Variation in Ovine <i>KRTAP13-3</i> and Its Association with Wool Characteristics in Chinese Tan SheepLingrong Bai0Huitong Zhou1Jinzhong Tao2Jon G. H. Hickford3International Wool Research Institute, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, ChinaInternational Wool Research Institute, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, ChinaInternational Wool Research Institute, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, ChinaInternational Wool Research Institute, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, ChinaUnderstanding the genetic factors that influence wool quality is essential for enhancing wool quality and uniformity. This study investigated the <i>KRTAP13-3</i> gene in Chinese Tan sheep, a breed known for its unique wool characteristics. We analysed 232 sheep and revealed five previously identified sequence variants of <i>KRTAP13-3</i> and then modelled to ascertain whether there was any association between the nucleotide sequence variation and variation in mean fibre diameter (MFD), fibre diameter standard deviation (FDSD), coefficient of variation of fibre diameter (CVFD), and mean fibre curvature (MFC). Twelve genotypes were observed, with the five variants having frequencies that ranged from 64.0% to 1.1%. Among the four variants with frequencies above 5%, nucleotide sequence variation was associated with heterotypic hair fibre diameter variation. The most common variant (<i>A</i>) was linked to increased FDSD and CVFD, while two other variants (<i>B</i> and <i>D</i>) revealed trends towards being associated with decreased CVFD. No associations were found with variation in the fine wool fibres from the Tan sheep. This suggests that <i>KRTAP13-3</i> plays a role in regulating heterotypic hair fibre diameter variability and that it could possibly be a gene marker for improving wool traits.https://www.mdpi.com/2076-2615/15/7/1069keratin-associated protein 13-3 genepolymorphismFDSDCVFDheterotypic hairChinese Tan sheep |
| spellingShingle | Lingrong Bai Huitong Zhou Jinzhong Tao Jon G. H. Hickford Variation in Ovine <i>KRTAP13-3</i> and Its Association with Wool Characteristics in Chinese Tan Sheep Animals keratin-associated protein 13-3 gene polymorphism FDSD CVFD heterotypic hair Chinese Tan sheep |
| title | Variation in Ovine <i>KRTAP13-3</i> and Its Association with Wool Characteristics in Chinese Tan Sheep |
| title_full | Variation in Ovine <i>KRTAP13-3</i> and Its Association with Wool Characteristics in Chinese Tan Sheep |
| title_fullStr | Variation in Ovine <i>KRTAP13-3</i> and Its Association with Wool Characteristics in Chinese Tan Sheep |
| title_full_unstemmed | Variation in Ovine <i>KRTAP13-3</i> and Its Association with Wool Characteristics in Chinese Tan Sheep |
| title_short | Variation in Ovine <i>KRTAP13-3</i> and Its Association with Wool Characteristics in Chinese Tan Sheep |
| title_sort | variation in ovine i krtap13 3 i and its association with wool characteristics in chinese tan sheep |
| topic | keratin-associated protein 13-3 gene polymorphism FDSD CVFD heterotypic hair Chinese Tan sheep |
| url | https://www.mdpi.com/2076-2615/15/7/1069 |
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