IgA Vasculitis – An In-Depth Literature Review
Introduction and Objective: Immunoglobulin A vasculitis (IgAV), previously Henoch-Schönlein purpura, is a systemic leukocytoclastic vasculitis of small vessels, characterised by the deposition of immunoglobulin A complexes in their walls. It represents the most prevalent form of vasculitis in child...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nicolaus Copernicus University in Toruń
2025-07-01
|
| Series: | Quality in Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/QS/article/view/62348 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849423309229260800 |
|---|---|
| author | Julia Dulęba Krzysztof Sajewicz Aleksandra Mazur Oskar Tudaj Monika Kaźmierczak Joanna Koszałko Filip Kin Paulina Strzałkowska Julia Kalisiak Wiktoria Kalas |
| author_facet | Julia Dulęba Krzysztof Sajewicz Aleksandra Mazur Oskar Tudaj Monika Kaźmierczak Joanna Koszałko Filip Kin Paulina Strzałkowska Julia Kalisiak Wiktoria Kalas |
| author_sort | Julia Dulęba |
| collection | DOAJ |
| description |
Introduction and Objective: Immunoglobulin A vasculitis (IgAV), previously Henoch-Schönlein purpura, is a systemic leukocytoclastic vasculitis of small vessels, characterised by the deposition of immunoglobulin A complexes in their walls. It represents the most prevalent form of vasculitis in children and may progress to IgA nephropathy, the leading cause of primary glomerulonephritis. This review provides a comprehensive overview of IgAV, covering its epidemiology, pathogenesis, clinical features, diagnosis, treatment, complications, and prognosis.
Materials and Methods: A narrative review was conducted, using PubMed articles up to 2024, focusing on recent data. Key sources included clinical guidelines (EULAR/PRINTO/PRES 2010 for paediatrics, ACR 1990 for adults) and contemporary studies on genetic, immunological, and therapeutic aspects. Data were synthesised to compare disease presentation and management in children and adults.
Results and Conclusions: IgAV predominantly affects children aged 3–15 years (incidence 3.0–27.0 per 100,000), often triggered by upper respiratory tract infections. In adults, the condition is rarer but more severe. Diagnosis relies on clinical criteria, with biopsy reserved for atypical cases. Treatment is primarily symptomatic, employing glucocorticoids for acute symptoms and immunosuppressive agents for severe cases. Complications, such as gastrointestinal and renal disorders, are more frequent in adults. Prognosis is favourable, with 94% of paediatric cases resolving within two years, although adults are at greater risk of chronic kidney disease and relapses. Early intervention and monitoring are critical for improving outcomes.
|
| format | Article |
| id | doaj-art-2a71f180487b4bfea5b0c232ad8762de |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-2a71f180487b4bfea5b0c232ad8762de2025-08-20T03:30:39ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-07-014310.12775/QS.2025.43.62348IgA Vasculitis – An In-Depth Literature ReviewJulia Dulęba0https://orcid.org/0009-0009-1465-0809Krzysztof Sajewicz1https://orcid.org/0009-0007-2274-400XAleksandra Mazur2https://orcid.org/0009-0001-5037-0080Oskar Tudaj3https://orcid.org/0009-0003-6934-459XMonika Kaźmierczak4https://orcid.org/0009-0005-8868-8368Joanna Koszałko5https://orcid.org/0009-0008-0790-0809Filip Kin6https://orcid.org/0009-0008-9017-2901Paulina Strzałkowska7https://orcid.org/0009-0000-7495-5561Julia Kalisiak8https://orcid.org/0009-0002-2432-0773Wiktoria Kalas9https://orcid.org/0009-0001-5051-1365University Clinical Hospital in PoznańUniversity Clinical Hospital in PoznańUniversity Clinical Hospital in PoznańIndependent Public Complex of Health Care Facilities of the Ministry of Interior and Administration in PoznańIndependent Public Complex of Health Care Facilities of the Ministry of Interior and Administration in PoznańUniversity Clinical Hospital in PoznańUniversity Clinical Hospital in PoznańUniversity Clinical Hospital in PoznańUniversity of Zielona GóraUniversity of Zielona Góra Introduction and Objective: Immunoglobulin A vasculitis (IgAV), previously Henoch-Schönlein purpura, is a systemic leukocytoclastic vasculitis of small vessels, characterised by the deposition of immunoglobulin A complexes in their walls. It represents the most prevalent form of vasculitis in children and may progress to IgA nephropathy, the leading cause of primary glomerulonephritis. This review provides a comprehensive overview of IgAV, covering its epidemiology, pathogenesis, clinical features, diagnosis, treatment, complications, and prognosis. Materials and Methods: A narrative review was conducted, using PubMed articles up to 2024, focusing on recent data. Key sources included clinical guidelines (EULAR/PRINTO/PRES 2010 for paediatrics, ACR 1990 for adults) and contemporary studies on genetic, immunological, and therapeutic aspects. Data were synthesised to compare disease presentation and management in children and adults. Results and Conclusions: IgAV predominantly affects children aged 3–15 years (incidence 3.0–27.0 per 100,000), often triggered by upper respiratory tract infections. In adults, the condition is rarer but more severe. Diagnosis relies on clinical criteria, with biopsy reserved for atypical cases. Treatment is primarily symptomatic, employing glucocorticoids for acute symptoms and immunosuppressive agents for severe cases. Complications, such as gastrointestinal and renal disorders, are more frequent in adults. Prognosis is favourable, with 94% of paediatric cases resolving within two years, although adults are at greater risk of chronic kidney disease and relapses. Early intervention and monitoring are critical for improving outcomes. https://apcz.umk.pl/QS/article/view/62348Immunoglobulin A vasculitisHenoch-Schönlein purpuraleukocytoclastic vasculitisIgA nephropathypaediatric vasculitisadult vasculitis |
| spellingShingle | Julia Dulęba Krzysztof Sajewicz Aleksandra Mazur Oskar Tudaj Monika Kaźmierczak Joanna Koszałko Filip Kin Paulina Strzałkowska Julia Kalisiak Wiktoria Kalas IgA Vasculitis – An In-Depth Literature Review Quality in Sport Immunoglobulin A vasculitis Henoch-Schönlein purpura leukocytoclastic vasculitis IgA nephropathy paediatric vasculitis adult vasculitis |
| title | IgA Vasculitis – An In-Depth Literature Review |
| title_full | IgA Vasculitis – An In-Depth Literature Review |
| title_fullStr | IgA Vasculitis – An In-Depth Literature Review |
| title_full_unstemmed | IgA Vasculitis – An In-Depth Literature Review |
| title_short | IgA Vasculitis – An In-Depth Literature Review |
| title_sort | iga vasculitis an in depth literature review |
| topic | Immunoglobulin A vasculitis Henoch-Schönlein purpura leukocytoclastic vasculitis IgA nephropathy paediatric vasculitis adult vasculitis |
| url | https://apcz.umk.pl/QS/article/view/62348 |
| work_keys_str_mv | AT juliaduleba igavasculitisanindepthliteraturereview AT krzysztofsajewicz igavasculitisanindepthliteraturereview AT aleksandramazur igavasculitisanindepthliteraturereview AT oskartudaj igavasculitisanindepthliteraturereview AT monikakazmierczak igavasculitisanindepthliteraturereview AT joannakoszałko igavasculitisanindepthliteraturereview AT filipkin igavasculitisanindepthliteraturereview AT paulinastrzałkowska igavasculitisanindepthliteraturereview AT juliakalisiak igavasculitisanindepthliteraturereview AT wiktoriakalas igavasculitisanindepthliteraturereview |