Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population.

Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population.

The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to multiple sclerosis (MS) susceptibility, with 32 independent effects across the region explaining 20% of the heritability in European populations. Variation is high across populations with allele frequency difference...

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Main Authors: Ashley H Beecham, Lilyana Amezcua, Angel Chinea, Clara P Manrique, Lissette Gomez, Andrea Martinez, Gary W Beecham, Nikolaos A Patsopoulos, Tanuja Chitnis, Howard L Weiner, Philip L De Jager, Esteban G Burchard, Brett T Lund, Kathryn C Fitzgerald, Peter A Calabresi, Silvia R Delgado, Jorge R Oksenberg, Jacob L McCauley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0279132&type=printable
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