White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities
Abstract White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including...
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2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1016/j.trci.2019.02.001 |
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| author | Jessica Alber Suvarna Alladi Hee‐Joon Bae David A. Barton Laurel A. Beckett Joanne M. Bell Sara E. Berman Geert Jan Biessels Sandra E. Black Isabelle Bos Gene L. Bowman Emanuele Brai Adam M. Brickman Brandy L. Callahan Roderick A. Corriveau Silvia Fossati Rebecca F. Gottesman Deborah R. Gustafson Vladimir Hachinski Kathleen M. Hayden Alex M. Helman Timothy M. Hughes Jeremy D. Isaacs Angela L. Jefferson Sterling C. Johnson Alifiya Kapasi Silke Kern Jay C. Kwon Juraj Kukolja Athene Lee Samuel N. Lockhart Anne Murray Katie E. Osborn Melinda C. Power Brittani R. Price Hanneke F.M. Rhodius‐Meester Jacqueline A. Rondeau Allyson C. Rosen Douglas L. Rosene Julie A. Schneider Henrieta Scholtzova C. Elizabeth Shaaban Narlon C.B.S. Silva Heather M. Snyder Walter Swardfager Aron M. Troen Susanne J. vanVeluw Prashanthi Vemuri Anders Wallin Cheryl Wellington Donna M. Wilcock Sharon Xiangwen Xie Atticus H. Hainsworth |
| author_facet | Jessica Alber Suvarna Alladi Hee‐Joon Bae David A. Barton Laurel A. Beckett Joanne M. Bell Sara E. Berman Geert Jan Biessels Sandra E. Black Isabelle Bos Gene L. Bowman Emanuele Brai Adam M. Brickman Brandy L. Callahan Roderick A. Corriveau Silvia Fossati Rebecca F. Gottesman Deborah R. Gustafson Vladimir Hachinski Kathleen M. Hayden Alex M. Helman Timothy M. Hughes Jeremy D. Isaacs Angela L. Jefferson Sterling C. Johnson Alifiya Kapasi Silke Kern Jay C. Kwon Juraj Kukolja Athene Lee Samuel N. Lockhart Anne Murray Katie E. Osborn Melinda C. Power Brittani R. Price Hanneke F.M. Rhodius‐Meester Jacqueline A. Rondeau Allyson C. Rosen Douglas L. Rosene Julie A. Schneider Henrieta Scholtzova C. Elizabeth Shaaban Narlon C.B.S. Silva Heather M. Snyder Walter Swardfager Aron M. Troen Susanne J. vanVeluw Prashanthi Vemuri Anders Wallin Cheryl Wellington Donna M. Wilcock Sharon Xiangwen Xie Atticus H. Hainsworth |
| author_sort | Jessica Alber |
| collection | DOAJ |
| description | Abstract White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia. |
| format | Article |
| id | doaj-art-2a6cfb46554d4acda1930faf7198468e |
| institution | OA Journals |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-2a6cfb46554d4acda1930faf7198468e2025-08-20T02:09:55ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-015110711710.1016/j.trci.2019.02.001White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunitiesJessica Alber0Suvarna Alladi1Hee‐Joon Bae2David A. Barton3Laurel A. Beckett4Joanne M. Bell5Sara E. Berman6Geert Jan Biessels7Sandra E. Black8Isabelle Bos9Gene L. Bowman10Emanuele Brai11Adam M. Brickman12Brandy L. Callahan13Roderick A. Corriveau14Silvia Fossati15Rebecca F. Gottesman16Deborah R. Gustafson17Vladimir Hachinski18Kathleen M. Hayden19Alex M. Helman20Timothy M. Hughes21Jeremy D. Isaacs22Angela L. Jefferson23Sterling C. Johnson24Alifiya Kapasi25Silke Kern26Jay C. Kwon27Juraj Kukolja28Athene Lee29Samuel N. Lockhart30Anne Murray31Katie E. Osborn32Melinda C. Power33Brittani R. Price34Hanneke F.M. Rhodius‐Meester35Jacqueline A. Rondeau36Allyson C. Rosen37Douglas L. Rosene38Julie A. Schneider39Henrieta Scholtzova40C. Elizabeth Shaaban41Narlon C.B.S. Silva42Heather M. Snyder43Walter Swardfager44Aron M. Troen45Susanne J. vanVeluw46Prashanthi Vemuri47Anders Wallin48Cheryl Wellington49Donna M. Wilcock50Sharon Xiangwen Xie51Atticus H. Hainsworth52Department of Biomedical and Pharmaceutical SciencesGeorge & Anne Ryan Institute for Neuroscience, University of Rhode IslandKingstonRIUSADepartment of NeurologyNational Institute of Mental Health and NeurosciencesBengaluruKarnatakaIndiaCerebrovascular Disease CenterSeoul National University Bundang HospitalSeongnamKoreaDepartment of PsychiatryUniversity of MelbourneMelbourneAustraliaDepartment of Public Health SciencesSchool of Medicine University of CaliforniaDavisCAUSASyneos HealthWilmingtonNCUSAWisconsin Alzheimer's Disease Research CenterMedical Scientist Training ProgramUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSADepartment of Neurology and NeurosurgeryBrain Center Rudolf Magnus Institute, University Medical Center UtrechtUtrechtThe NetherlandsDepartment of MedicineUniversity of Toronto, Sunnybrook Research InstituteTorontoONCanadaDepartment of Psychiatry & Neuropsychology, Alzheimer Centre LimburgSchool for Mental Health & Neuroscience, Maastricht UniversityMaastrichtThe NetherlandsDepartment of MedicineHarvard Medical SchoolBostonMAUSANeuro‐Bio LtdCulham Science CentreAbingdonUKTaub Institute for Research on Alzheimer's Disease and the Aging BrainDepartment of NeurologyCollege of Physicians and Surgeons, Columbia UniversityNew YorkNYUSADepartment of PsychologyUniversity of Calgary & Hotchkiss Brain InstituteCalgaryABCanadaDepartment of PsychologyUniversity of Calgary & Hotchkiss Brain InstituteCalgaryABCanadaDepartments of Neurology and PsychiatryNYU School of MedicineNew YorkNYUSADivision of Cerebrovascular NeurologyJohns Hopkins University School of MedicineBaltimoreMDUSASection for NeuroEpidemiologyState University of New YorkDownstate Medical CenterBrooklynNYUSAWestern UniversityLondon Health Sciences CentreLondonONCanadaDepartment of Social Sciences and Health PolicyDivision of Public Health SciencesWake Forest School of MedicineWinston‐SalemNCUSAUniversity of KentuckySanders‐Brown Center on AgingLexingtonKYUSADepartment of Internal Medicine – Section of Gerontology and Geriatric MedicineDepartment of Epidemiology and PreventionWake Forest School of MedicineWinston‐SalemNCUSASt George's University of LondonDepartment of NeurologySt George's University Hospitals NHS Foundation TrustLondonUKVanderbilt Memory & Alzheimer's CenterVanderbilt University Medical CenterNashvilleTNUSADepartment of Medicine‐GeriatricsInstitute on Aging, University of Wisconsin‐MadisonMadisonWIUSADepartment of Pathology (Neuropathology)Rush Alzheimer's Disease CenterChicagoILUSADepartment of Psychiatry and NeurochemistryInstitute of Neuroscience and Physiology, Sahlgrenska Academy at the University of GothenburgGothenburgSwedenDepartment of NeurologyChangwon Fatima HospitalChangwonKoreaDepartment of Neurology and Clinical NeurophysiologyHelios University Hospital WuppertalWuppertalGermanyDepartment of Psychiatry and Human BehaviorAlpert Medical School of Brown UniversityProvidenceRIUSADepartment of Internal Medicine – Section of Gerontology and Geriatric MedicineWake Forest School of MedicineWinston‐SalemNCUSABerman Center for Outcomes and Clinical Research20298 Minneapolis Medical Research FoundationMinneapolisMNUSAVanderbilt Memory & Alzheimer's CenterVanderbilt University Medical CenterNashvilleTNUSADepartment of Epidemiology and BiostatisticsMilken Institute School of Public Health, George Washington UniversityWashingtonDCUSASanders Brown Center on AgingUniversity of KentuckyLexingtonKYUSAAlzheimer CenterDepartment of NeurologyVU University Medical Centre, Amsterdam NeuroscienceAmsterdamThe NetherlandsMontclair Memory ClinicMontclairNJUSADepartment of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordCAUSAAnatomy & NeurobiologyBoston University School of MedicineBostonMAUSARush Alzheimer's Disease CenterRush University Medical CenterChicagoILUSADepartment of NeurologyNYU School of MedicineNew YorkNYUSADepartment of EpidemiologyGraduate School of Public Health & Center for the Neural Basis of Cognition, University of PittsburghPittsburghPAUSASchool of KinesiologyWestern Centre for Public Health & Family MedicineLondonONCanadaDivision of Medical and Scientific RelationsAlzheimer's AssociationChicagoILUSASunnybrook Research Institute, University of TorontoTorontoONCanadaInstitute of Biochemistry Food Science and NutritionThe Robert H. Smith Faculty of Agriculture Food and EnvironmentThe Hebrew University of JerusalemJerusalemIsraelDepartment of NeurologyMassachusetts General Hospital, Harvard Medical SchoolBostonMAUSADepartment of RadiologyMayo Clinic RochesterRochesterMNUSAInstitute of Neuroscience and Physiology, Sahlgrenska Academy at University of GothenburgGothenburgSwedenDepartment of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain HealthUniversity of British ColumbiaVancouverBCCanadaSanders‐Brown Center on AgingDepartment of PhysiologyUniversity of KentuckyLexingtonKYUSADepartment of Biostatistics, Epidemiology and InformaticsUniversity of PennsylvaniaPhiladelphiaPAUSAMolecular & Clinical Sciences Research Institute, St George's University of LondonDepartment of NeurologySt George's University Hospitals NHS Foundation TrustLondonUKAbstract White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.https://doi.org/10.1016/j.trci.2019.02.001Vascular dementiaVascular cognitive impairmentLeukoaraiosisWhite matter lesionsSmall vessel disease |
| spellingShingle | Jessica Alber Suvarna Alladi Hee‐Joon Bae David A. Barton Laurel A. Beckett Joanne M. Bell Sara E. Berman Geert Jan Biessels Sandra E. Black Isabelle Bos Gene L. Bowman Emanuele Brai Adam M. Brickman Brandy L. Callahan Roderick A. Corriveau Silvia Fossati Rebecca F. Gottesman Deborah R. Gustafson Vladimir Hachinski Kathleen M. Hayden Alex M. Helman Timothy M. Hughes Jeremy D. Isaacs Angela L. Jefferson Sterling C. Johnson Alifiya Kapasi Silke Kern Jay C. Kwon Juraj Kukolja Athene Lee Samuel N. Lockhart Anne Murray Katie E. Osborn Melinda C. Power Brittani R. Price Hanneke F.M. Rhodius‐Meester Jacqueline A. Rondeau Allyson C. Rosen Douglas L. Rosene Julie A. Schneider Henrieta Scholtzova C. Elizabeth Shaaban Narlon C.B.S. Silva Heather M. Snyder Walter Swardfager Aron M. Troen Susanne J. vanVeluw Prashanthi Vemuri Anders Wallin Cheryl Wellington Donna M. Wilcock Sharon Xiangwen Xie Atticus H. Hainsworth White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities Alzheimer’s & Dementia: Translational Research & Clinical Interventions Vascular dementia Vascular cognitive impairment Leukoaraiosis White matter lesions Small vessel disease |
| title | White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities |
| title_full | White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities |
| title_fullStr | White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities |
| title_full_unstemmed | White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities |
| title_short | White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities |
| title_sort | white matter hyperintensities in vascular contributions to cognitive impairment and dementia vcid knowledge gaps and opportunities |
| topic | Vascular dementia Vascular cognitive impairment Leukoaraiosis White matter lesions Small vessel disease |
| url | https://doi.org/10.1016/j.trci.2019.02.001 |
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