Administration of Ascorbic Acid Alleviates Neuronal Damage After Cerebral Ischemia in ODS Rats

Administration of Ascorbic Acid Alleviates Neuronal Damage After Cerebral Ischemia in ODS Rats

Reactive oxygen species (ROS) contribute to cerebral damage in transient cerebral ischemia, making their elimination a key therapeutic target. Osteogenic disorder Shionogi (ODS) rats, which lack endogenous L-ascorbic acid (AA) synthesis, serve as a useful model for investigating AA’s protective effe...

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Bibliographic Details
Main Authors: Naohiro Iwata, Naoto Ogawa, Tom Imai, Siti Sabirah Binti Ridzuan, Shinya Kamiuchi, Hirokazu Matsuzaki, Meiyan Xuan, Bo Yuan, Mari Okazaki, Yasuhide Hibino
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antioxidants
Subjects:
L-ascorbic acid (AA)
osteogenic disorder Shionogi (ODS) rat
middle cerebral artery occlusion and reperfusion (MCAO/Re)
reactive oxygen species (ROS)
neuronal apoptosis
pro-inflammatory cytokines
Online Access:https://www.mdpi.com/2076-3921/14/7/773
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